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Leading Edge Acceleration Projects (LEAP) in Health Information Technology

ID: NAP-AX-26-001 • Type: Posted
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Description

While working to implement Cures Act provisions, ONC identified gaps with respect to leveraging EHR data to support population-level analyses and delivery of services, as well as integrating clinical knowledge into routine clinical practice. The reasons for these gaps range from a lack of data standards and interoperability to the digitization, integration, and presentation of new evidence into clinical workflows in safe, useful, and useable ways.

Therefore, this funding opportunity will support innovative and breakthrough solutions critical to maximize the potential of health IT and achieve the goal of a transformed health care delivery system through various methods, such as:

Determining the fundamental questions, the answers to which will identify barriers to nationwide interoperability and electronic exchange of health data.

Engaging the health IT industry, along with academic researchers, to identify and develop innovative solutions that address barriers to interoperability.

Disseminating findings from research while fostering collaboration, advancement, and implementation of solutions and lessons learned with the health IT industry.

Structure and Approach

ONC expects to award three cooperative agreements for a project period of two years for each recipient to focus on areas where breakthrough improvements are needed to address problems that have impeded the innovative use of health IT and thereby accelerate progress in the areas identified.

Areas of Interest

The three Areas of Interest identified below describe priorities ONC is interested in continuing to explore and advance. The descriptions include ways in which applicants may approach developing a project. The Areas of Interest have been assigned numbers for ease of reference, not for prioritization. While there are many challenges associated with the use of health IT, these three Areas of Interest have been identified as critical priority areas for ONC.

Area 1: Accelerate the use of agentic artificial intelligence solutions in clinical care and/or clinical trials

Goal

ONC seeks proposals in this area of interest to accelerate the use of standards-based agentic artificial intelligence (AI) technologies to advance clinical care and enable innovation through AI. The area of interest builds on the recently released request for information Accelerating the Adoption and Use of Artificial Intelligence as Part of Clinical Care.

Area 2: Expand Lantern's API monitoring capabilities by integrating secure, community-driven feedback that complements existing automated checks Goal The goal of this area of interest is to enhance Lantern's ability to monitor FHIR endpoints by adding a secure, community driven feedback layer that complements existing automated checks. This project will enable implementers, vendors, app developers, and certification bodies to share actionable information about real world API behavior, improving reliability, transparency, and trust in FHIR APIs across the health care ecosystem.

Area 3: Assess laboratory interoperability gaps to improve the adoption and use of standard terminology among small, independent laboratories

Goal

The goals of this area of interest are to assess laboratory data quality and implement existing solutions aimed at improving the adoption and use of standard codes such as Logical Observation Identifiers Names and Codes (LOINC), SNOMED Clinical Terms (SNOMED CT), and Unified Codes for Units of Measure (UCUM) among small, independent laboratories. Projects should assess laboratory data quality and use that information to identify and pilot test different solutions (such as mapping tools) to facilitate the use of correct codes in laboratory data and to transition small, independent laboratories from using local laboratory codes to using standardized terminologies. Projects should focus on solutions that support conformance with national laboratory standards and can be widely implemented by small, independent laboratories.

Background
The Leading Edge Acceleration Projects (LEAP) in Health Information Technology is a funding opportunity issued by the U.S. Department of Health and Human Services, specifically the Office of the National Coordinator for Health Information Technology (ONC).

The ONC's mission is to coordinate nationwide efforts to implement advanced health IT and facilitate the electronic exchange of health information. This funding aims to address gaps identified in leveraging Electronic Health Record (EHR) data for population-level analyses and service delivery, as well as integrating clinical knowledge into routine practice. The goal is to support innovative solutions that maximize health IT potential and transform healthcare delivery systems.

Grant Details
The LEAP funding opportunity focuses on three Areas of Interest:
1. **Accelerate the use of agentic artificial intelligence solutions in clinical care and/or clinical trials**: Projects should develop or adapt AI solutions for specific workflows, conduct pilot projects demonstrating functionality, integrate with health IT systems, evaluate risks, and publish findings.

2. **Expand Lantern’s API monitoring capabilities**: This involves enhancing Lantern's ability to monitor FHIR endpoints by integrating community-driven feedback to improve API reliability and transparency. Key objectives include identifying valuable performance information, creating a technical solution for data collection, developing visualizations, and generating machine-readable reports.

3. **Assess laboratory interoperability gaps**: Projects should assess laboratory data quality and implement solutions to improve the adoption of standard terminologies like LOINC among small laboratories. Objectives include conducting readiness assessments, pilot testing tools for data quality improvement, and disseminating findings through reports and educational workshops.

Eligibility Requirements
Eligible applicants include public or non-profit private institutions (e.g., universities), local or state government units, eligible federal agencies, Indian/Native American Tribal Governments, and certain consortia involving for-profit organizations or foreign institutions as sub-recipients only. Organizations engaging in lobbying activities under section 501(c)4 are not eligible.

Period of Performance
The anticipated project period is from September 26, 2026, to September 25, 2029, with an initial budget period from September 26, 2026, to September 25, 2028.

Grant Value
The total available funding is approximately $2 million across three awards: up to $1 million for Area of Interest 1 and up to $500,000 each for Areas of Interest 2 and 3.

Place of Performance
The geographic location(s) for performance are expected to be within the United States.

Overview

Category of Funding
Health
Other (see text field entitled "Explanation of Other Category of Funding Activity" for clarification)
Funding Instruments
Cooperative Agreement
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
On 6/16/26 the Office of the National Coordinator for Health Information Technology posted grant opportunity NAP-AX-26-001 for Leading Edge Acceleration Projects (LEAP) in Health Information Technology. The grant will be issued under grant program 93.345 Leading Edge Acceleration Projects (LEAP) in Health Information Technology. It is expected that 3 total grants will be made worth between $500,000 and $1.0 million.

Timing

Posted Date
June 16, 2026, 12:00 a.m. EDT
Closing Date
July 16, 2026, 12:00 a.m. EDT Due in 28 Days
Closing Date Explanation
No Explanation
Last Updated
June 16, 2026, 4:08 p.m. EDT
Version
3
Archive Date
Aug. 15, 2026

Eligibility

Eligible Applicants
Native American tribal governments (Federally recognized)
Private institutions of higher education
Public and State controlled institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Additional Info
For-profit organizations may participate in projects as members of a consortia or as a sub-recipient only. Because the purpose of this NOFO is to improve health care in the United States, foreign institutions may participate in projects as members of a consortia or as a sub-recipient only. Applications submitted by for-profit organizations or foreign institutions will not be reviewed. Organizations described in section 501(c)4 of the Internal Revenue Code that engage in lobbying activities are not eligible.

Award Sizing

Ceiling
$1,000,000
Floor
$500,000
Estimated Program Funding
Not Provided
Estimated Number of Grants
3

Contacts

Contact
Office of the National Coordinator
Contact Email
Email Description
Grants.gov Customer Support
Contact Phone
(202) 205-5621
Additional Information
Leading Edge Acceleration Projects (LEAP) in Health Information Technology

Documents

Posted documents for NAP-AX-26-001

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