Kidney Precision Medicine Project Central Hub

The National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the continuation of the Kidney Precisions Medicine Project (KPMP). The Kidney Precision Medicine Project (KPMP) was started in FY2017 with the vision to safely and ethically collect and interrogate human kidney biopsy tissue to discover novel molecular pathways that promote Chronic Kidney Diseases (CKDs) or Acute Kidney Injuries (AKIs). It was expanded in FY2022 to enhance participant recruitment and tissue interrogation.

Consistent with the recommendation of an External Evaluation Committee (2/14/2025), the NIDDK proposes to extend the KPMP for 5 years. This NOFO will utilize the U01 and U24 activity codes. This extension will allow the KPMP to (1) honor its commitment to existing enrollees (~500) by continuing robust longitudinal clinical follow-up, (2) achieve additional power by enrolling new participants (>500) for in-depth molecular interrogation and follow-up, and (3) accelerate the discovery and validation of novel pathways, targets, and disease subgroups by directly supporting the efforts of the broader research community to fully leverage KPMP data.

This renewal includes a single U24 for clinical and data coordination, integration, analysis, and sharing. In addition, up to 14 U01 awards will be distributed between a) recruitment sites to support new participant recruitment, kidney biopsy, and longitudinal participant observational data collection and b) Tissue Interrogation Sites which interrogate the tissue with state-of-the-art methodologies stringent quality requirements. All components of this award work collaboratively on scientific data analysis and discovery to meet the scientific objectives of the project.