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Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Therapeutic Agent Characterization and Preclinical Efficacy Studies

ID: PAR-26-057 • Type: Forecasted
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Description

The National Institute of Neurological Disorders and Stroke, National Institute of Aging, the NIH Helping to End Addiction Long Term (HEAL) initiative, and other participating ICs seek to support applications to conduct pharmacodynamic, pharmacokinetic, and efficacy studies to demonstrate that the proposed therapeutic agent(s) have sufficient biological activity to warrant further development as therapeutics for disorders or diseases supported by participating ICs or for non-opioid analgesic therapeutics with little or no addiction liability as a part of the NIH HEAL initiative. Therapeutic agents include small molecules or biologics. Efficacy testing can be conducted in validated in vivo models and/or validated New Approach Methodologies (NAMs) as appropriate.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

Background
The National Institute of Neurological Disorders and Stroke, National Institute of Aging, and the NIH Helping to End Addiction Long Term (HEAL) initiative aim to support applications for pharmacodynamic, pharmacokinetic, and efficacy studies. The goal is to demonstrate that proposed therapeutic agents have sufficient biological activity for further development as therapeutics for specific disorders or diseases or as non-opioid analgesic therapeutics with minimal addiction liability.

Grant Details
The grant focuses on conducting studies to characterize therapeutic agents, which may include small molecules or biologics. Efficacy testing can be performed in validated in vivo models or through validated New Approach Methodologies (NAMs). The specific tasks include conducting pharmacodynamic and pharmacokinetic studies to assess the biological activity of the therapeutic agents.

Eligibility Requirements
Eligibility requirements are implied; applicants should have the capability to conduct relevant pharmacological studies and collaborations with participating ICs.

Period of Performance
The period of performance for this contract is one year from the date of award, specifically from 10-27-2024 to 10-26-2025.

Grant Value
The total value of the grant and potential value of individual grant awards are not specified.

Place of Performance
The work will be performed at the Mt. Weather Emergency Operations Center (MWEOC), located at 19844 Blueridge Mountain Road, Bluemont, VA.
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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Grant
Grant Program (CFDA)
93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 2/25/26 the National Institutes of Health forecasted grant opportunity PAR-26-057 for Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Therapeutic Agent Characterization and Preclinical Efficacy Studies. The grant will be issued under grant program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.

Timing

Forecast Posted Date
Feb. 25, 2026, 12:00 a.m. EST
Est. Application Posting Date
July 30, 2026, 12:00 a.m. EDT
Est. Synopsis Response Date
Sept. 30, 2026, 12:00 a.m. EDT Forecasted
Last Updated
Feb. 25, 2026, 2:51 p.m. EST
Version
1

Eligibility

Eligible Applicants
Public housing authorities/Indian housing authorities
Special district governments
City or township governments
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
State governments
Public and State controlled institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Native American tribal governments (Federally recognized)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
County governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Info
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Contacts

Contact
NINDS_IGNITE@nih.gov
Contact Email
ninds_ignite@nih.gov   Profile

Documents

Posted documents for PAR-26-057

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