Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) (U01 Clinical Trial Optional)

Background
The grant is issued by the National Institute of Mental Health (NIMH) under the Department of Health and Human Services. The purpose of the grant is to stimulate and support research that will use behavioral measures and computational methods to define novel clinical signatures that can be used for individual-level prediction and clinical decision making in mental disorders.

Grant Details
The grant aims to encourage research using novel behavioral measures to foster a new generation of clinical signatures, leading toward precision assessment, prognosis, and treatment of mental disorders. The research will focus on developing or optimizing behavioral tasks that measure individual differences and demonstrate added utility for clinical prediction when combined with standard clinical diagnosis. It also involves forming a data infrastructure that can support computational approaches to build tools for clinical decision making.

The proposed research projects should focus on integrating data collected via behavioral tasks and measures with data available via clinical records. Behavioral tasks and measures may include computerized tasks administered via web- or device-based platforms and/or passive collection of behavioral data (including speech, mobility, and sleep patterns) via mobile or wearable devices. The grant also requires a Plan for Enhancing Diverse Perspectives (PEDP) to advance the scientific and technical merit of the proposed project through expanded inclusivity.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, state and local governments, federal agencies, U.S. territories or possessions, foreign organizations, and other entities such as public housing authorities, faith-based or community-based organizations, regional organizations, and Native American tribal organizations. Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

Period of Performance
The period of performance is expected to start in October 2024 with an expiration date in October 2029. The maximum project period is 5 years.

Grant Value
$15 million total in FY 2025 for this NOFO to fund up to 6 U01 awards. Application budgets are limited to no more than $2,500,000 direct costs per year.