Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) (U01 Clinical Trial Optional)

Background
The grant opportunity, titled 'Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) (U01 Clinical Trial Optional)', is issued by the National Institutes of Health (NIH) and specifically by the National Institute of Mental Health (NIMH). The purpose of this grant is to stimulate and support research that will use behavioral measures and computational methods to define novel clinical signatures that can be used for individual-level prediction and clinical decision making in mental disorders. The grant aims to foster a new generation of clinical signatures leading toward precision assessment, prognosis, and treatment of mental disorders.

Grant Details
The grant seeks to fund research projects that will identify and/or develop behavioral tasks optimized for measurement of individual differences in individuals with or at risk of developing mental disorders. It also aims to collect data from novel clinical cohorts and/or identify existing datasets that include behavioral data and other data typically available in the clinical record. The grant further intends to derive novel clinical signatures that incorporate behavioral measures and information derived from the clinical record, partner with a Data Coordinating Center (DCC), and develop data structures designed to enable machine learning and related algorithms.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, state governments, federal governments, U.S. territories or possessions, foreign institutions, and other entities as specified in the NOFO. Individuals with the skills, knowledge, and resources necessary to carry out the proposed research as Program Director(s)/Principal Investigator(s) are invited to work with their organization to develop an application for support.

Grant Value
The National Institute of Mental Health (NIMH) intends to commit $30 million total in FY 2024 for this grant opportunity to fund up to 8 U01 awards and 1-2 U24 awards. Application budgets are limited to no more than $2,500,000 direct costs per year. The maximum project period is 5 years.