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Human Islet Research Network - Consortium on Human Islet Biomimetics (HIRN-CHIB) (UG3/UH3 Clinical Trial Not Allowed)

ID: RFA-DK-18-011 • Type: Posted
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Description

This FOA invites new applications to participate in the Human Islet Research Network-Consortium on Human Islet Biomimetics (HIRN-CHIB). NIDDK will support the development of a microphysiological system (MPS) that allows the study of interactions between primary human islets or assembled islet spheroids (organoids made up of human beta/alpha/delta/other cells) and immune cells within a 3D microenvironment to mimic aspects of the autoimmune process and its regulation. The ultimate goal will be to create an in vitro human disease model(s) that could recapitulate some aspects of the complex pathophysiology of Type 1 diabetes (T1D), by using T1D patient-derived islets (created using induced pluripotent stem cells (iPSCs) combined with autologous immune components. CHIB is already part of HIRN, whose overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans.

Overview

Category of Funding
Food and Nutrition
Health
Funding Instruments
Cooperative Agreement
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
On 8/10/18 the National Institutes of Health posted grant opportunity RFA-DK-18-011 for Human Islet Research Network - Consortium on Human Islet Biomimetics (HIRN-CHIB) (UG3/UH3 Clinical Trial Not Allowed) with funding of $3.0 million. The grant will be issued under grant program 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.

Timing

Posted Date
Aug. 10, 2018, 12:00 a.m. EDT
Closing Date
Dec. 11, 2018, 12:00 a.m. EST Past Due
Version
1
Archive Date
Jan. 16, 2019

Eligibility

Eligible Applicants
Special district governments
Native American tribal organizations (other than Federally recognized tribal governments)
For profit organizations other than small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
State governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
Private institutions of higher education
Independent school districts
City or township governments
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Public and State controlled institutions of higher education
Additional Info
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Award Sizing

Ceiling
$750,000
Floor
Not Listed
Estimated Program Funding
$3,000,000
Estimated Number of Grants
Not Listed

Contacts

Contact
National Institutes of Health
Contact Email
Email Description
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster
Contact Phone
(301) 496-3405

Documents

Posted documents for RFA-DK-18-011

Grant Awards

Grants awarded through RFA-DK-18-011

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