Health Promotion and Disease Prevention Research Centers: 2025 Special Interest Project Competitive Supplements (SIPS)

Background
The Centers for Disease Control and Prevention (CDC), specifically the National Center for Chronic Disease Prevention and Health Promotion, is issuing this Notice of Funding Opportunity (NOFO) to provide supplemental funding to CDC Health Promotion and Disease Prevention Research Centers (PRCs).

The goal of this funding is to conduct Special Interest Projects (SIPs) that inform public health practice through high-quality applied health promotion and disease prevention research in real-world settings. This initiative aims to identify, design, test, assess, evaluate, disseminate, and translate interventions that can prevent and reduce risks associated with the leading causes of illness, disability, and death in the United States.

Grant Details
The NOFO supports seven specific SIPs:
1) Validating survey questions on prostate cancer screening including PSA testing and shared decision-making;
2) Prostate cancer active surveillance identification using electronic health records;
3) Practice-based evidence on approaches for accurate identification and appropriate selection of individuals for lung cancer screening;
4) Lifestyle Change Implementation Research Network (LCIRN);
5) Understanding the potential of early childcare and education centers in promoting childhood vaccines and RSV prevention products;
6) Overdose Prevention and Treatment Research Network (OPTRN);
7) Scaling What Works within the National Comprehensive Cancer Control Program.

Recipients will engage in activities such as identifying strategies for intervention design, testing developed interventions for efficacy, conducting dissemination research, and implementing strategies to sustain interventions in public health practice.

Eligibility Requirements
Eligible applicants must be institutions approved for funding under CDC Notice of Funding Opportunity RFA-DP-24-004. Foreign organizations are not eligible to apply. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are encouraged to apply. Each institution can submit only one application per SIP.

Period of Performance
The total period of performance is four years, from September 30, 2025, to September 29, 2029.

Grant Value
The estimated total funding available for this NOFO is $21,858,000. It is anticipated that up to 12 awards will be made under this NOFO with an award ceiling of $5,902,000 per budget period.

Place of Performance
The grant activities will be performed at various CDC Health Promotion and Disease Prevention Research Centers across the United States.