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FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program

ID: DE-FOA-0003600 • Type: Posted
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Description

The Office of Science (SC) of the Department of Energy (DOE) hereby announces its continuing interest in receiving applications for support of work in the following program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production. On September 3, 1992, DOE published in the Federal Register the Office of Energy Research Financial Assistance Program (now called the Office of Science Financial Assistance Program), 10 CFR 605, as a Final Rule, which contained a solicitation for this program. Information about submission of applications, eligibility, limitations, evaluation and selection processes and other policies and procedures are specified in 10 CFR 605.

This NOFO is our annual open solicitation that covers all research areas in SC and is open throughout the Fiscal Year. Any research within SC's Congressionally authorized mission may be proposed under this NOFO.

This NOFO will remain open until September 30, 2026, 11:59 PM Eastern Time, or until it is succeeded by another issuance, whichever occurs first. This NOFO succeeds DE-FOA-0003432, which was published September 30, 2024.

Background
The Office of Science (SC) of the Department of Energy (DOE) announces its ongoing interest in receiving applications for support in various program areas including Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production.

This Notice of Funding Opportunity (NOFO) serves as an annual open solicitation covering all research areas within SC's Congressionally authorized mission. The NOFO remains open until September 30, 2026, or until replaced by a successor NOFO.

Grant Details
The grant supports research in the following areas:
1. Advanced Scientific Computing Research (ASCR) - focuses on applied mathematics, computer science, computational partnerships, and advanced computing technologies.
2. Basic Energy Sciences (BES) - includes materials chemistry, biomolecular materials, synthesis and processing science, and various physics disciplines.
3. Biological and Environmental Research (BER) - covers microbiome research and environmental systems process research.
4. Fusion Energy Sciences (FES) - involves theory & simulation and artificial intelligence applications in fusion science.
5. High Energy Physics (HEP) - includes experimental and theoretical research across energy frontiers.
6. Nuclear Physics (NP) - focuses on nuclear structure and astrophysics among other topics.
7. Isotope R&D and Production (IRP) - involves isotope production research and radiochemical synthesis.

Eligibility Requirements
All types of applicants are eligible to apply except nonprofit organizations described in section 501(c)(4) of the Internal Revenue Code that engaged in lobbying activities after December 31, 1995. Federally affiliated entities must adhere to specific eligibility standards outlined in the NOFO.

Period of Performance
The period of performance for awards is expected to range from six months to five years, with most common project periods being three years.

Grant Value
Approximately $500 million is expected to be available for funding across current and future fiscal years. Historically, individual awards have ranged from $5,000 to $5 million.

Place of Performance
The specific geographic locations for performance are implied to be within the United States as part of DOE's mission.
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Overview

Agency
Office of Science (OS) [DOE]
Category of Funding
Science and Technology and other Research and Development
Funding Instruments
Cooperative Agreement
Grant
Other
Grant Program (CFDA)
81.049 - Office of Science Financial Assistance Program
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 9/30/25 the Office of Science posted grant opportunity DE-FOA-0003600 for FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program with funding of $500.0 million. The grant will be issued under grant program 81.049 Office of Science Financial Assistance Program. It is expected that 500 total grants will be made worth between $50,000 and $5.0 million.

Timing

Posted Date
Sept. 30, 2025, 12:00 a.m. EDT
Closing Date
Sept. 30, 2026, 12:00 a.m. EDT Due in 119 Days
Last Updated
Sept. 30, 2025, 7:58 a.m. EDT
Version
1
Archive Date
Oct. 30, 2026

Eligibility

Eligible Applicants
Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

Award Sizing

Ceiling
$5,000,000
Floor
$50,000
Estimated Program Funding
$500,000,000
Estimated Number of Grants
500

Contacts

Contact
Michael S Zarkin Grants Management Specialist
Contact Email
sc.opencall@science.doe.gov   Profile
Email Description
Open Call
Contact Phone
(301) 903-4946
Additional Information
Office of Science
Additional Information Site
https://science.osti.gov

Documents

Posted documents for DE-FOA-0003600

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