Exploring Proteogenomic Approaches to Unravel the Mechanisms of Mis-Folded Protein Accumulation in Tauopathies (R01 Clinical Trial Not Allowed)

Background
This funding opportunity is issued by the National Institute on Aging (NIA), which is part of the National Institutes of Health (NIH). The purpose of the grant is to explore the accumulation of misprocessed proteins in Tauopathies within specific brain regions and cell types. The goal is to understand dynamic changes in protein-misfolding responses in neuronal proteomes and their potential biological consequences during aging and the development of Alzheimer's Disease (AD) and AD-Related Dementias (ADRD).

Grant Details
The grant aims to provide a proof-of-principal for a novel strategy to identify misprocessed and aberrant proteins in Tau diseases using the proteogenomic approach. It encourages collaborative efforts to create advanced single-cell or single-cell type proteogenomic platforms. The research objectives include creating a comprehensive database of misprocessed and aberrant proteins in selected mouse models of human Tau diseases, cross-validating the presence of misprocessed and aberrant proteins in human AD/ADRD brains, identifying new molecular pathways and novel misprocessed protein-protein interaction networks, defining novel mechanisms through which misprocessed and aberrant proteins influence neurodegeneration, and identifying disease-specific therapeutic targets. Applications that only provide a global view of gene expression without any subcellular, cell-type, and brain regional specificity will be considered non-responsive.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, state and local governments, federally recognized Indian/Native American tribal governments, federal agencies, U.S. territories or possessions, public housing authorities/Indian housing authorities, Native American tribal organizations (other than federally recognized tribal governments), faith-based or community-based organizations, regional organizations, and foreign organizations. Foreign components of U.S. organizations are also eligible to apply.

Period of Performance
The period of performance for the grant is up to 5 years.

Grant Value
The National Institute on Aging (NIA) intends to commit $4,000,000 in FY 2024 to fund 4-6 awards. Application budgets may not exceed $500,000 in direct costs per year.