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Exploratory/Developmental Research on Guillain Barre Syndrome (GBS) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) (R21 - Clinical Trial Not Allowed)

ID: RFA-NS-25-025 • Type: Posted

Description

The purpose of this initiative are to accelerate research leading to improved understanding and treatments for Guillain Barre Syndrome (GBS) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Responsive applications would propose studies of immunological mechanisms of nerve damage/dysfunction, contributing genetic/epigenetic factors, novel animal/cellular model systems, discovery of novel diagnostic or treatment response biomarkers, novel treatments or mechanisms of action of existing treatments.
Background
The National Institutes of Health (NIH), specifically the National Institute of Neurological Disorders and Stroke (NINDS), is issuing this funding opportunity to support exploratory and developmental research aimed at understanding, preventing, or treating Guillain Barre Syndrome (GBS) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP).

The goal is to accelerate research that leads to improved understanding and treatments for these rare autoimmune neuropathies, which cause damage to peripheral nerves.

Grant Details
The grant will support studies focused on:
1) Immunological mechanisms of nerve damage/dysfunction;
2) Contributing genetic/epigenetic factors;
3) Novel animal/cellular model systems;
4) Discovery of novel diagnostic or treatment response biomarkers;
5) Development of novel treatments or mechanisms of action of existing treatments.

Applications must propose innovative studies that address these areas and may not include clinical trials.

Eligibility Requirements
Eligible applicants include higher education institutions, public/state controlled institutions, private institutions, nonprofits, for-profit organizations, small businesses, local governments, state governments, tribal governments, federal agencies, and foreign organizations. Individuals from diverse backgrounds are encouraged to apply.

Period of Performance
The total project period may not exceed two years. The anticipated start date for successful applications is March 3, 2025.

Grant Value
NIH intends to commit an estimated total of $3,000,000 to fund approximately 7 awards. The combined budget for direct costs may not exceed $275,000 over the two-year project period, with no more than $200,000 requested in any single year.

Overview

Category of Funding
Health
Funding Instruments
Grant
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
On 11/13/24 the National Institutes of Health posted grant opportunity RFA-NS-25-025 for Exploratory/Developmental Research on Guillain Barre Syndrome (GBS) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) (R21 - Clinical Trial Not Allowed) with funding of $3.0 million. The grant will be issued under grant program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.

Timing

Posted Date
Nov. 13, 2024, 12:00 a.m. EST
Closing Date
Oct. 3, 2025, 12:00 a.m. EDT Due in 113 Days
Last Updated
Nov. 13, 2024, 10:59 a.m. EST
Version
1
Archive Date
Nov. 8, 2025

Eligibility

Eligible Applicants
Private institutions of higher education
Small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Public and State controlled institutions of higher education
For profit organizations other than small businesses
State governments
Public housing authorities/Indian housing authorities
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
County governments
Native American tribal organizations (other than Federally recognized tribal governments)
City or township governments
Native American tribal governments (Federally recognized)
Additional Info
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Award Sizing

Ceiling
$3,000,000
Floor
Not Listed
Estimated Program Funding
$3,000,000
Estimated Number of Grants
Not Listed

Contacts

Contact
National Institutes of Health
Contact Email
Email Description
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Contact Phone
(301) 402-2541
Additional Information
https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-025.html

Documents

Posted documents for RFA-NS-25-025

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