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Expanding the Therapeutic Pipeline for Treating and Preventing Alzheimer's Disease and Related Dementias: Preclinical Validation and Drug Discovery for Novel Candidate Targets (U01 Clinical Trial Not Allowed)

ID: PAR-26-132 • Type: Forecasted
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Description

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on Alzheimer's disease (AD) and AD-related dementias (ADRD) drug target validation and early-stage drug discovery against novel targets. This NOFO will utilize the U01 activity code. The NOFO will support rigorous preclinical AD/ADRD drug target validation and early-stage drug discovery of small molecules, biologic, and emerging therapeutic modalities. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into AD/ADRD and drug discovery are encouraged to begin to consider applying for this new NOFO.

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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Program (CFDA)
93.866 - Aging Research
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 3/4/26 the National Institutes of Health forecasted grant opportunity PAR-26-132 for Expanding the Therapeutic Pipeline for Treating and Preventing Alzheimer's Disease and Related Dementias: Preclinical Validation and Drug Discovery for Novel Candidate Targets (U01 Clinical Trial Not Allowed). The grant will be issued under grant program 93.866 Aging Research.

Timing

Forecast Posted Date
March 4, 2026, 12:00 a.m. EST
Est. Application Posting Date
July 31, 2026, 12:00 a.m. EDT
Est. Synopsis Response Date
Oct. 5, 2026, 12:00 a.m. EDT Forecasted
Last Updated
March 4, 2026, 3:18 p.m. EST
Version
1

Eligibility

Eligible Applicants
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Independent school districts
Public and State controlled institutions of higher education
State governments
Native American tribal organizations (other than Federally recognized tribal governments)
Small businesses
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Special district governments
County governments
Private institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Info
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Contacts

Contact
NIA Scientific Contact
Contact Email
nia-nofo-scientific@nih.gov

Documents

Posted documents for PAR-26-132

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