Emergency Awards: HEAL Initiative-Limited Competition: HEAL Initiative Resource Centers for the Pain Management Effectiveness Research Network (ERN) (U24 Clinical Trial Not Allowed)

NCATS is issuing this FOA in response to the declared public health emergency issued by the Secretary, HHS. Please see Determination that a Public Health Emergency Exists Nationwide as the Result of the Opioid Crisis as renewed in Renewal of the Determination that a Public Health Emergency Exists Nationwide as the Result of the Continued Consequences of the Opioid Crisis. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to continue support of Resource Center activities funded under RFA-TR-15-002 and RFA-TR-15-004; thus only applicants funded by RFA-TR-15-002 and RFA-TR-15-004 are eligible to apply for this FOA. Applications to this FOA will support Resource Centers (RCs) for clinical trials funded through the HEAL Pain Management Effectiveness Research Network (ERN) initiatives, including those funded under RFA-NS-19-021 and RFA-NS-20-028. Applicants are expected to continue provision of the existing HEAL ERN infrastructure to support comparative effectiveness clinical trials/studies with a shared common theme of improving pain management and reducing the reliance on opioid medications when appropriate. The RCs will provide clinical and data coordination, biostatistical resources, and recruitment and retention support. They will also continue working with other HEAL Data Coordination Resource Centers (DCRCs) to harmonize data elements creating valuable combined data sets that can be used for future meta-analyses or to add to our knowledge of under-studied pain conditions.