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DoD Toxic Exposures Clinical Trial Partnership Award

ID: HT942525TERPCTPA • Type: Posted
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Description

Summary: The intent of the FY25 Toxic Exposures Research Program (TERP) Clinical Trial Partnership Award (CTPA) is to support new or existing collaborative partnerships that will rapidly implement clinical trials with the potential to have a significant impact on the prevention, treatment or management of symptoms, diseases, or conditions associated with or resulting from military-related toxic exposures. Proposed projects may range from small proof-of-concept clinical trials (e.g., pilot, first-in-human, phase 0) designed to demonstrate the feasibility or inform the design of more advanced trials through large-scale trials (including pragmatic clinical trials) to determine efficacy in relevant patient populations.

Distinctive Features: To encourage applications that include meaningful and productive collaborations between investigators, the FY25 TERP CTPA requires partnership of the Initiating Principal Investigator (PI) with at least one, and up to two, other collaborating PIs for the completion of one overarching study.

Background
The FY25 Toxic Exposures Research Program (TERP) Clinical Trial Partnership Award (CTPA) is issued by the Department of Defense (DoD) with the mission to support collaborative partnerships that implement clinical trials aimed at addressing health issues related to military-related toxic exposures. The program aims to facilitate research that can significantly impact prevention, treatment, or management of symptoms and diseases arising from such exposures.

The TERP was initiated by Congress in FY22, with a vision to improve health outcomes for Service Members, their Families, Veterans, and the American public affected by toxic exposures.

Grant Details
The CTPA supports clinical trials ranging from small proof-of-concept studies to large-scale pragmatic trials. Projects must demonstrate meaningful collaboration between an Initiating Principal Investigator (PI) and at least one or two Partnering PIs. The award encourages innovative approaches in evaluating new products, pharmacologic agents, devices, and emerging technologies.

Proposed studies must align with at least one FY25 TERP Program Goal and Topic Area, focusing on military-related toxic exposures. Key areas include predicting and preventing exposures, elucidating mechanisms of adverse effects, diagnosing exposure impacts, developing therapeutics, and understanding multigenerational effects.

Eligibility Requirements
Eligible applicants include both extramural and intramural organizations such as academic institutions, biotechnology companies, foundations, and DOD organizations. Independent investigators at all career levels can serve as PIs. There are no specific cost-sharing requirements for eligibility.

Period of Performance
The maximum period of performance for the grant is 4 years.

Grant Value
The total funding available for this grant opportunity is approximately $4.2 million, with a cost cap of $4.2 million for each application.

Place of Performance
The grant does not specify geographic locations; however, it encourages recruitment from military and Veteran populations.
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Overview

Agency
U.S. Army Medical Research Acquisition Activity (USAMRAA) [DoD - USA - MEDCOM - MRDC]
Category of Funding
Science and Technology and other Research and Development
Funding Instruments
Grant
Grant Program (CFDA)
12.420 - Military Medical Research and Development
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 6/5/25 U.S. Army Medical Research Acquisition Activity posted grant opportunity HT942525TERPCTPA for DoD Toxic Exposures Clinical Trial Partnership Award with funding of $4.2 million. The grant will be issued under grant program 12.420 Military Medical Research and Development. It is expected that one grant will be made.

Timing

Posted Date
June 5, 2025, 12:00 a.m. EDT
Closing Date
Oct. 16, 2025, 12:00 a.m. EDT Due in 45 Days
Last Updated
June 5, 2025, 12:00 p.m. EDT
Version
3
Archive Date
Nov. 15, 2025

Eligibility

Eligible Applicants
Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
$4,200,000
Estimated Number of Grants
1

Contacts

Contact
Abigail Strock Contract Specialist
Contact Email
help@ebrap.org   Profile
Email Description
CDMRP Help Desk
Contact Phone
(301) 619-2342

Documents

Posted documents for HT942525TERPCTPA

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