DoD Peer Reviewed Medical, Technology Therapeutic Development Award

Background
The PRMRP Technology/Therapeutic Development Award (TTDA) is a product-driven award mechanism intended to provide support for the translation of promising preclinical findings into products for clinical applications, including prevention, detection, diagnosis, treatment, or quality of life, for a disease or condition related to one of the FY23 PRMRP Topic Areas and one of the FY23 PRMRP Strategic Goals. The vision of the PRMRP is to improve the health, well-being, and care of all military Service Members, Veterans, and Beneficiaries. The program seeks applications in laboratory, clinical, behavioral, epidemiological, and other areas of research to advance knowledge in disease etiology; improve prevention, detection, diagnosis, treatment, and quality of life for those affected by a relevant disease or condition; and develop and validate clinical practice or public health guidelines. The proposed research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public.

Grant Details
The PRMRP Technology/Therapeutic Development Award (TTDA) is intended to provide support for the translation of promising preclinical findings into products for clinical applications. The award mechanism may not be used to conduct clinical trials. Research proposed under this award mechanism may be at different stages of idea and research development.
Two different funding levels are available: Funding Level 1 with anticipated direct costs not exceeding $2M for research supported by significant preliminary data but has not advanced to clinical translation; Funding Level 2 with anticipated direct costs not exceeding $4M for research that is in the final stages of preclinical development with potential for near-term clinical development. The types of awards made under the program announcement will be assistance agreements in the form of a grant or cooperative agreement.

Eligibility Requirements
All organizations including foreign organizations, foreign public entities, international organizations, local, state, and federal government agencies within the United States are eligible to apply.
Principal Investigators (PIs) at or above the level of Assistant Professor (or equivalent) may be named by the organization as the PI on the application. Each investigator may be named on only one FY23 PRMRP TTDA application as a PI.

Period of Performance
The period of performance for an FY23 PRMRP Technology/Therapeutic Development Award will not exceed September 30, 2029.

Grant Value
$99M is expected to fund approximately 20 PRMRP Technology/Therapeutic Development Award applications.
The anticipated direct costs budgeted for the entire period of performance will not exceed $2M for Funding Level 1 awards and $4M for Funding Level 2 awards.

Place of Performance
Relevance to military health is a key feature of this award.
Investigators are encouraged to integrate and/or align their research projects with DOD and/or Department of Veterans Affairs (VA) research laboratories and programs. Collaboration with DOD or VA investigators is also encouraged.