DoD Peer Reviewed Medical Research Program, Clinical Trial Award

Background
The fiscal year 2025 (FY25) Peer Reviewed Medical Research Program (PRMRP) Clinical Trial Award (CTA) is managed by the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP).

The PRMRP was initiated in 1999 to support medical research projects that have clear scientific merit and direct relevance to military health. The mission of the PRMRP is to improve the health, care, and well-being of military Service Members, their Families, and Veterans. The FY25 appropriation for this program is $150 million, with a focus on rapid implementation of clinical trials addressing specific diseases or conditions outlined by Congress.

Grant Details
The CTA supports clinical trials that can significantly impact treatment or management of diseases relevant to military health. Key features include:
- Clinical trials are mandatory; animal studies are not permitted.
- All preclinical work must be completed before the award start date.
- The program expects to fund approximately 4 applications with total costs capped at $8 million each.
- Patient recruitment must begin no later than 9 months after the award date.
- Proposed projects can range from small proof-of-concept trials to large-scale comparative effectiveness trials.
- Applications must address one of the FY25 PRMRP topic areas and strategic goals, demonstrating relevance to military health.

Eligibility Requirements
Eligible applicants include both extramural and intramural organizations, including foreign and domestic entities, for-profit and non-profit organizations, as well as public or private entities. Principal Investigators must be at least at the level of Assistant Professor or equivalent. Each investigator can only be named as PI on one application for FY25 PRMRP funding.

Period of Performance
The maximum period of performance for funded projects is 4 years.

Grant Value
The total value allocated for this grant opportunity is approximately $32 million, with individual grant awards capped at $8 million.

Place of Performance
The specific geographic locations for performance are expected to align with military health needs.