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DoD Multiple Sclerosis, Investigator-Initiated Research Award

ID: HT9425-23-MSRP-IIRA • Type: Posted

Description

The IIRA supports highly rigorous, high-impact research projects that have the potential to make an important contribution to MS research and/or patient care. Research projects may focus on any phase of research, excluding clinical trials. The rationale for a research idea may be derived from laboratory discovery, clinical trial results, population-based studies, a clinician's firsthand knowledge of patients, or anecdotal data. Applications must include preliminary and/or published data that are relevant to MS and the proposed research project.

For the Correlates of Disease Activity and Progression in MS Focus Area, applications must demonstrate access to the relevant specimens and/or data of the proposed cohort. Refer to Attachment 8: Letter(s) Confirming Access to Specimens and/or Data for more details.

Note for projects involving animal models of MS: Applicants should be prudent in the choice of animal model(s) for their proposed research project. Applicants must justify the relevance of their proposed animal model(s) to the specific aspect of human MS to be studied.

New Investigator option: The FY23 MSRP IIRA mechanism encourages applications from investigators in the early stages of their MS research career. The New Investigator option is designed to support the continued development of promising independent investigators that are early in their faculty appointments. Applications from Established Investigators and New Investigators will be peer and programmatically reviewed in separate groups. Principal Investigators (PIs) applying under the New Investigator option are encouraged to strengthen their applications through collaboration with investigators experienced in MS research and/or possessing other relevant expertise as demonstrated by a record of funding and publications.

Background
The Department of Defense (DoD) Multiple Sclerosis Research Program (MSRP) is seeking highly rigorous, high-impact research projects relevant to the prevention, etiology, pathogenesis, assessment, and treatment of multiple sclerosis (MS) to ultimately lessen its personal and societal impact. The MSRP was initiated in 2009 to provide support for pioneering concepts and high-impact research in this field. The proposed research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public.

Grant Details
The FY23 MSRP Investigator-Initiated Research Award (IIRA) program announcement focuses on four main areas: Central Nervous System Repair, Protection, and Regenerative Potential in MS; Correlates of Disease Activity and Progression in MS; Biology and Measurement of MS Symptoms; and Factors Contributing to or Associated with MS Etiology, Prodrome, Onset, and Disease Course. The IIRA supports highly rigorous, high-impact research projects that have the potential to make an important contribution to MS research and/or patient care. Research projects may focus on any phase of research, excluding clinical trials. Applications must include preliminary and/or published data that are relevant to MS and the proposed research project.

Eligibility Requirements
All organizations including foreign organizations, foreign public entities, international organizations, local, state, and federal government agencies within the United States are eligible to apply. Principal Investigators (PIs) must be independent investigators at or above the level of Assistant Professor (or equivalent). The FY23 MSRP IIRA mechanism encourages applications from investigators in the early stages of their MS research career. The New Investigator option is designed to support promising independent investigators that are early in their faculty appointments.

Period of Performance
Pre-Application Submission Deadline: 5:00 p.m. Eastern time (ET), June 8, 2023.
Application Submission Deadline: 11:59 p.m. ET, October 6, 2023.
Awards will be made no later than September 30, 2024.

Grant Value
The anticipated total costs budgeted for the entire period of performance for an FY23 MSRP IIRA should not exceed $1.0M for both Established and New Investigator options.
Approximately $6.0M is expected to fund approximately six IIRA applications.
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Overview

Agency
U.S. Army Medical Research Acquisition Activity (USAMRAA) [DoD - USA - MEDCOM - MRDC]
Category of Funding
Science and Technology and other Research and Development
Funding Instruments
Cooperative Agreement
Grant
Grant Program (CFDA)
12.420 - Military Medical Research and Development
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 4/14/23 U.S. Army Medical Research Acquisition Activity posted grant opportunity HT9425-23-MSRP-IIRA for DoD Multiple Sclerosis, Investigator-Initiated Research Award with funding of $6.0 million. The grant will be issued under grant program 12.420 Military Medical Research and Development. It is expected that 6 total grants will be made.

Timing

Posted Date
April 14, 2023, 12:00 a.m. EDT
Closing Date
Oct. 6, 2023, 12:00 a.m. EDT Past Due
Last Updated
April 14, 2023, 12:23 p.m. EDT
Version
1
Archive Date
Nov. 5, 2023

Eligibility

Eligible Applicants
Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
$6,000,000
Estimated Number of Grants
6

Contacts

Contact
Jamie Shortall Grant Officer
Contact Email
help@ebrap.org   Profile
Email Description
CDMRP Help Desk
Contact Phone
(301) 619-2393

Documents

Posted documents for HT9425-23-MSRP-IIRA

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