Cohort Studies of HIV/AIDS and Substance Use (U01 Clinical Trial Not Allowed)

Background
The National Institute on Drug Abuse (NIDA) supports a program of longitudinal cohort studies that addresses the intersection of HIV and substance use. This program is a multidisciplinary platform to support basic, epidemiologic, and clinical research on HIV and HIV-associated co-morbidities and co-infections among populations with substance use and substance use disorders (SUDs) and to address research questions at the individual and population level.

Grant Details
Research by each site should focus on high-risk populations or PLWH, who use substances. This RFA will seek applications from investigators working with HIV populations most affected by HIV (i.e., those at highest risk or living with HIV) in the United States.

These can include sexual and gender minorities, racial/ethnic minorities, people involved in the criminal justice system and sex workers. Cohort populations should reflect social and economic characteristics of affected populations. Rural and metropolitan populations are welcome.

The initiative also targets priority jurisdictions identified by the Ending the HIV Epidemic (EHE) initiative, although other jurisdictions will be considered with an epidemiologic justification (e.g., rural counties affected by opioid epidemics). Applicants must demonstrate the capacity to: Be responsive to changes to substance use and HIV epidemics, such as new substance use patterns, introduction of new substances; emergent co-morbidities including infectious diseases such as Mpox, COVID-19 and others, changes to public health policies, or to HIV/substance use treatments or prevention strategies.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, federal government agencies, U.S. territories or possessions, independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations (other than federally recognized tribal governments), faith-based or community-based organizations, regional organizations. Foreign institutions are not eligible to apply.

Period of Performance
The project period is 5 years.

Grant Value
NIDA intends to commit $15,000,000 in FY25 to fund 8-10 awards.

Place of Performance
The grant will be performed in the United States.