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Clinical Research Network on Antimicrobial Resistance (UM1 Clinical Trial Required)

ID: RFA-AI-27-005 • Type: Posted
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Description

Background
The National Institutes of Health (NIH), specifically the National Institute of Allergy and Infectious Diseases (NIAID), is issuing this notice of funding opportunity (NOFO) to support a Clinical Research Network (CRN) focused on Antimicrobial Resistance (AMR).

The goal of the program is to design, implement, and manage clinical research that addresses critical clinical questions related to AMR through a coordinated and integrated network comprising four centers: the Scientific Leadership Center (SLC), the Clinical Operations Center (COC), the Laboratory Center (LC), and the Statistics and Data Coordination Center (SDCC).

This initiative aims to enhance biomedical research and training in infectious diseases, develop effective treatments, and optimize existing therapies to combat AMR.

Grant Details
The CRN will conduct comprehensive clinical research including trials, studies, and related activities aimed at improving prevention, diagnosis, and treatment of AMR infections. Key tasks include:
1. Exploration of innovative antimicrobial treatments and drug combinations targeting gram-negative and gram-positive bacterial pathogens as well as AMR fungal pathogens.
2. Strategy trials to optimize currently licensed antimicrobials while minimizing impacts on native microbial communities.
3. Investigations into diagnostic tests that refine treatment strategies for appropriate antimicrobial use.
4. Development of next-generation clinical researchers specializing in AMR research.
5. Establishing operational support for clinical studies through the COC, overseeing laboratory services through the LC, and providing statistical analysis through the SDCC.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, tribal governments, independent school districts, public housing authorities, faith-based organizations, and regional organizations. Foreign collaborations are not eligible to apply. Applicants must have experience in IND/IDE submissions and safety oversight reporting.

Period of Performance
The project period for this grant is set for 7 years.

Grant Value
NIAID intends to commit $18 million in FY 2027 to fund one award with application budgets not expected to exceed $12 million in direct costs per year.

Place of Performance
The specific geographic locations for performance may include applicant institutions or subcontracted clinical research sites.
Updated:
Amendment Snapshot: The opportunity changed from Forecasted to Posted. A posted application deadline is now November 10, 2026; the prior September 29, 2026 date was only an estimated forecast response date. Estimated funding increased from $15 million to $18 million. Eligibility is now expressly restricted: foreign organizations and non-U.S. components of U.S. organizations may not apply, and applications involving foreign subawards or subcontracts are noncompliant; foreign components and certain unfunded international arrangements remain allowed as described. The posted scope specifies a coordinated four-center network (SLC, COC, LC, and SDCC), replacing the broader forecast description. Archive date moved from August 31, 2026 to January 9, 2027. Contact information changed to NIH, including phone 301-402-2541 and an AMR network email.
Government Description:
The purpose of this notice of funding opportunity (NOFO) is to support a Clinical Research Network (CRN) on Antimicrobial Resistance (AMR). The program aims to design, implement, and manage clinical research that addresses pivotal clinical questions related to AMR through a coordinated and integrated CRN. The CRN will comprise four centers: the Scientific Leadership Center (SLC), the Clinical Operations Center (COC), the Laboratory Center (LC), and the Statistics and Data Coordination Center (SDCC). The purpose of this notice of funding opportunity (NOFO) is to support a Clinical Research Network (CRN) on Antimicrobial Resistance (AMR). The program aims to design, implement, and manage clinical research that addresses pivotal clinical questions related to AMR through a coordinated and integrated CRN. The CRN will comprise four centers: the Scientific Leadership Center (SLC), the Clinical Operations Center (COC), the Laboratory Center (LC), and the Statistics and Data Coordination Center (SDCC).
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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Program (CFDA)
93.855 - Allergy and Infectious Diseases Research
NAICS
541714 - Research and Development in Biotechnology (except Nanobiotechnology)
PSC
AN12 - Health R&D Services; Health Care Services; Applied Research
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 9/1/26 the National Institutes of Health posted grant opportunity RFA-AI-27-005 for Clinical Research Network on Antimicrobial Resistance (UM1 Clinical Trial Required) with funding of $18.0 million. The grant will be issued under grant program 93.855 Allergy and Infectious Diseases Research. It is expected that one grant will be made.

Timing

Posted Date
Closing Date
Due in 18 Days
Last Updated
Version
1
Archive Date

Eligibility

Eligible Applicants
Public housing authorities/Indian housing authorities
State governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Special district governments
County governments
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
City or township governments
Independent school districts
Additional Info
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
$18,000,000
Estimated Number of Grants
1

Contacts

Contact
National Institutes of Health
Contact Email
amrclinicalresearchnetworkcontact@mail.nih.gov
Contact Phone
(301) 402-2541

Documents

Posted documents for RFA-AI-27-005

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