ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed)

Background
NIH established a clinical genomics infrastructure to develop an openly accessible knowledgebase that promotes data sharing and provides standardized infrastructure and tools for determining the clinical relevance of genetic variants through two initiatives: the Clinical Genomics Resource (ClinGen) and the Clinical Variant Database (ClinVar) of clinical variation. ClinGen defines the clinical relevance of genes and variants for use in precision medicine and research by standardizing clinical annotation and interpretation of variants and implementing evidence-based expert consensus assertions.

Grant Details
This Notice of Funding Opportunity (NOFO) aims to establish Expert Panels that will select genes and genomic variants associated with diseases or conditions of high priority to participating NIH Institutes and Centers (ICs) and systematically determine their clinical significance for diagnosis and treatment of these diseases or conditions. The Genomic Curation Expert Panels funded through this NOFO are required to utilize the NHGRI Clinical Genomics Resource (ClinGen) and the NCBI ClinVar procedures, interfaces, tools, and informatics infrastructure.

The scope of this NOFO is to establish Expert Panels in areas of high priority to the participating ICs. The Expert Panel will select and review genes and/or genetic variants within the specified domain that have the potential for clinical applicability utilizing the procedures and tools developed by ClinGen.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, state governments, county governments, city or township governments, special district governments, Indian/Native American Tribal Governments (Federally Recognized), U.S. Territory or Possession, independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), faith-based or community-based organizations, regional organizations. Foreign Institutions are not eligible to apply.

Period of Performance
The maximum project period is 3 years.

Grant Value
Application budgets are limited to $220,000 per year in direct costs.