Cellular and Biochemical Engineering

The Cellular and Biochemical Engineering (CBE)program is part of the Engineering Biology and Health cluster, which also includes 1) Biophotonics; 2) Biosensing; 3) Disability and Rehabilitation Engineering; and 4) Engineering of Biomedical Systems. TheCellular and Biochemical Engineering program supports fundamental engineering research that advances understanding of cellular andbiomolecular processes in engineering biology. CBE-funded research eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cell, biochemical, biopharmaceutical, and biotechnology industries. Fundamental to many research projects in this area is the understanding of how biomolecules, subcellular systems, cells, and cell populations interact in the biomanufacturing environment, and how those interactions lead to changes in structure, function, and behavior. A quantitative treatment of problems related to biological processes is considered vital to successful research projects in the CBE program. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches. The CBE program also encourages proposals that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities. Major areas of interest in the program include:

• Metabolic engineering and synthetic biology for biomanufacturing, including the design of synthetic metabolic components and synthetic cells,
• Quantitative systems biotechnology,
• Cell culture technologies,
• Protein and enzyme engineering, and
• Single cell dynamics and modeling in the context of biomanufacturing.

All proposals should include a description on the potential impact of proposed research on an associated biomanufacturing process. Proposals whose core innovation involves tissue engineering or organ culture should be submitted to the Engineering ofBiomedicalSystems program (5345). The duration of unsolicited awards is generally one to three years. The typical award size for the program is around $100,000 per year with allowance for up to $200,000 per year for collaborative projects involving multiple institutions. Proposals requesting a substantially higher amount than this, without prior consultation with the Program Director, may be returned without review. INFORMATION COMMON TO MOST CBET PROGRAMS Proposals should address the novelty and/orpotentially transformative natureof the proposed work compared to previous work in the field. Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact of success in the research on society and/or industry. The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. Faculty Early Career Development(CAREER)program proposals are strongly encouraged. Award duration is five years. The submission deadline for Engineering CAREER proposals is in July every year. Please see the CAREER URLherefor more information. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the Program Director before submission of the proposal. Grants forRapid Response Research(RAPID)andEArly-concept Grants for Exploratory Research(EAGER)are also considered when appropriate. Please note that proposals of these types must be discussed with the program director before submission. Further details are available in theProposal and Award Policies and Procedures Guide(PAPPG)download foundhere.Grant Opportunities for Academic Liaison with Industry (GOALI)proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that GOALI proposals must be submitted during the annual unsolicited proposal window for each program. More information on GOALI can be foundhere. COMPLIANCE: Proposals which are not compliant with theProposal and Award Policies and Procedures Guide (PAPPG)will be returned without review.