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BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)

ID: RFA-NS-27-001 • Type: Posted
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Description

Posted: Feb. 9, 2026, 12:00 a.m. EST
This notice of funding opportunity (NOFO) supports efforts to disseminate resources for integration into neuroscience research practice. The resource(s) should be relevant to the goals of the BRAIN Initiative as outlined in the "BRAIN 2025: A Scientific Vision" and "The BRAIN Initiative 2.0: From Cells to Circuits, Toward Cures" and shared broadly to the neuroscience community. The resource(s) should address compelling needs of neuroscience researchers that are otherwise unavailable or impractical in their current form. Activities must include dissemination of an existing resource, and may include one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and/or specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community.
Posted: May 9, 2025, 12:00 a.m. EDT
Posted: May 9, 2025, 12:00 a.m. EDT
Posted: May 9, 2025, 12:00 a.m. EDT
Posted: May 9, 2025, 12:00 a.m. EDT
Background
The BRAIN Initiative, launched in 2014, aims to accelerate the development and application of innovative neurotechnologies to enhance our understanding of the brain. This funding opportunity supports efforts to disseminate resources that integrate into neuroscience research practice, aligning with the goals outlined in 'BRAIN 2025: A Scientific Vision' and 'The BRAIN Initiative 2.0: From Cells to Circuits, Toward Cures'. The initiative seeks to address compelling needs of neuroscience researchers by providing resources that are otherwise unavailable or impractical in their current form.

Grant Details
The grant supports activities that include the dissemination of existing resources relevant to neuroscience research. Specific tasks may involve:
- Distribution of tools and reagents;
- User training on new technologies or techniques;
- Providing access to existing technology platforms and specialized facilities;
- Minor improvements to increase resource production and delivery efficiency;
- Adaptations to meet user community needs.

Projects should focus on producing and distributing reagents, providing customized instrumentation, maintaining open-source computational models, and enabling user facilities for external scientists. Applications must demonstrate clear value to a broad community of investigators.

Eligibility Requirements
Eligible applicants include higher education institutions (public and private), nonprofits, for-profit organizations (including small businesses), local governments, state governments, tribal governments, and other entities. Non-domestic entities are not eligible to apply. Applicants must have the necessary skills and resources to carry out the proposed research.

Period of Performance
Support may be requested for up to 5 years with a possibility of one renewal. The earliest start date for projects is June 10, 2026.

Grant Value
The NIH anticipates providing $10 million per year for this initiative, funding an estimated 10 to 20 awards. Application budgets are not limited but should reflect the actual needs of the proposed project.

Overview

Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
On 2/9/26 the National Institutes of Health posted grant opportunity RFA-NS-27-001 for BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed) with funding of $10.0 million. The grant will be issued under grant program 93.372 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies. It is expected that 20 total grants will be made.

Timing

Posted Date
Feb. 9, 2026, 12:00 a.m. EST
Closing Date
Oct. 6, 2028, 12:00 a.m. EDT Due in 937 Days
Last Updated
Feb. 9, 2026, 7:09 a.m. EST
Version
1
Archive Date
Dec. 5, 2028

Eligibility

Eligible Applicants
State governments
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Special district governments
County governments
Small businesses
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
Public housing authorities/Indian housing authorities
Private institutions of higher education
Public and State controlled institutions of higher education
Additional Info
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
$10,000,000
Estimated Number of Grants
20

Contacts

Contact
National Institutes of Health
Contact Phone
(301) 402-2541

Documents

Posted documents for RFA-NS-27-001

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