BRAIN Initiative Cell Atlas Network (BICAN): Comprehensive Center on Human and Non-human Primate Brain Cell Atlases (UM1 Clinical Trial Not Allowed)

Background
The BRAIN Initiative aims to accelerate the development and application of innovative neurotechnologies, enabling researchers to produce a new dynamic picture of the brain that reveals how individual cells and complex neural circuits interact in both time and space. The National Institutes of Health (NIH) is one of several federal agencies involved in the BRAIN Initiative, with contributions initially guided by 'BRAIN 2025: A Scientific Vision,' a strategic plan that detailed seven high-priority research areas.

Grant Details
This Funding Opportunity Announcement (FOA) intends to support large-scale Comprehensive Center(s) that will adopt high throughput imaging technology platforms to create comprehensive and highly granular brain cell atlases of human and non-human primates with an emphasis on human. The Centers are expected to characterize all brain cell types (neurons, glia, and other non-neuronal cells) at high-resolution. The Centers will establish advanced high throughput imaging technology platform and data pipelines for large-scale data production. They are expected to optimize and streamline individual steps and processes from brain specimen collection, preservation, dissection, sample processing, through data generation, visualization, analysis, mapping, and integration.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, state governments, county governments, city or township governments, special district governments, Indian/Native American Tribal Governments (Federally Recognized), Indian/Native American Tribal Governments (Other than Federally Recognized), U.S. Territory or Possession entities, independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), faith-based or community-based organizations, regional organizations, non-domestic (non-U.S.) entities (foreign institutions), domestic or foreign components of U.S. Organizations.

Period of Performance
The maximum project period is 5 years.

Grant Value
The National Institutes of Health (NIH) intends to commit an estimated total of $30M per fiscal year to fund 1-3 Comprehensive Centers.