Assessment of TBI-related ADRD Pathology Related to Cognitive Impairment and Dementia Outcomes (U01 - Clinical Trial Not Allowed)

Background
The National Plan to Address Alzheimer’s Disease aims to prevent and effectively treat Alzheimer's disease (AD) and Alzheimer’s disease-related dementias (ADRDs) by 2025. The National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS) held research summits to assess the needs and set AD/ADRD research implementation milestones. The NINDS ADRD Summit 2022 resulted in ADRD research priorities for advancing the state-of-the-science toward meeting Goal 1 of the National Plan.

Grant Details
This Notice of Funding Opportunity (NOFO) invites applications for a multisite study to comprehensively characterize ADRD relevant pathology related to cognitive impairment and dementia outcomes in post-mortem brains from persons with a history of traumatic brain injury (TBI). Investigations should elucidate the contribution of key individual and injury characteristics to evaluate associations between neuropathological burden and antemortem clinicopathologic symptoms, outline the prevalence of TBI-related ADRD diagnoses, and CTE pathology in the specimen collected from participating brain banks. The NOFO intends to support studies that include at least one trainee and/or early-stage investigator (ESI), specifically a neuropathologist on the research team.

Eligibility Requirements
Eligible applicants include higher education institutions, nonprofits, for-profit organizations, state governments, federal agencies, U.S. territories or possessions, public housing authorities/Indian housing authorities, Native American tribal organizations, faith-based or community-based organizations. Foreign institutions are not eligible to apply. Individuals from diverse backgrounds are encouraged to apply for NIH support.

Period of Performance
The maximum project period is 5 years with an earliest start date of July 28, 2023.

Grant Value
NIH intends to commit a total budget of up to $4,000,000 per year to fund two awards, contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Application budgets are limited to no more than $1,300,000 in direct costs per year.