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Advancing Real-World Effectiveness Evidence for Rapid-Acting Psychotropic Interventional Drugs (RAPIDs)

ID: RFA-MH-27-150 • Type: Forecasted
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Description

The National Institute of Mental Health (NIMH) intends to publish a Notice of Funding Opportunity (NOFO) to support the development of a research network to study rapid-acting psychotropic interventional drugs (RAPIDs), such as ketamine, esketamine, psilocybin, and other emerging treatments for serious mental illnesses.

Preliminary studies suggest that RAPIDs can produce clinically meaningful improvements in mental health outcomes, in some cases following a single dose. However, important questions remain regarding their effectiveness, safety, durability of benefit, and implementation in routine clinical practice. As these interventions move toward broader use, rigorous real-world evidence is needed to identify how RAPIDs can be delivered safely, effectively, and sustainably across diverse patients, providers, and health care settings.

The primary goal of this NOFO is to generate actionable evidence on the clinical effectiveness, safety, and implementation of RAPIDs. The resulting evidence from this study will help determine how RAPIDs can be safely and effectively integrated into clinical care and may inform future approaches to health care delivery.

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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Program (CFDA)
93.242 - Mental Health Research Grants
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 9/16/26 the National Institutes of Health forecasted grant opportunity RFA-MH-27-150 for Advancing Real-World Effectiveness Evidence for Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) with funding of $20.0 million. The grant will be issued under grant program 93.242 Mental Health Research Grants. It is expected that 3 total grants will be made.

Timing

Forecast Posted Date
Est. Application Posting Date
Est. Synopsis Response Date
Forecasted
Last Updated
Version
1

Eligibility

Eligible Applicants
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Independent school districts
Private institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Small businesses
State governments
County governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
City or township governments
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Info
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
$20,000,000
Estimated Number of Grants
3

Contacts

Contact
Division of Services and Intervention Research
Contact Email
nimhrapids@nih.gov

Documents

Posted documents for RFA-MH-27-150

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