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Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)

ID: PAR-26-040 • Type: Posted
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Description

Posted: Feb. 11, 2026, 12:00 a.m. EST
The National Library of Medicine (NLM) seeks applications for research projects that drive groundbreaking innovation and advanced development in the fields of bioinformatics, translational bioinformatics, and computational biology. The primary goal of this initiative is to support the creation and implementation of cutting-edge methods, tools, and approaches that can transform the landscape of biomedical data science. This NOFO aims to address the growing need to leverage transformative technologies such as artificial intelligence (AI), machine learning, and large-scale computational platforms to extract actionable knowledge from vast, diverse, and complex biological datasets. By enabling more effective interpretation and integration of multi-dimensional biological and biomedical data, this research will ultimately contribute to improving individual and population health outcomes.
Posted: July 22, 2025, 12:00 a.m. EDT
Posted: July 22, 2025, 12:00 a.m. EDT
Posted: July 22, 2025, 12:00 a.m. EDT
Background
The National Library of Medicine (NLM), part of the National Institutes of Health (NIH), seeks applications for research projects that drive innovation in bioinformatics, translational bioinformatics, and computational biology.

The initiative aims to support the development of advanced methods and tools that can transform biomedical data science, leveraging technologies such as artificial intelligence (AI) and machine learning to extract actionable insights from complex biological datasets. This research is intended to improve health outcomes for individuals and populations.

Grant Details
The grant supports research that advances bioinformatics and biomedical computing by focusing on the creation and implementation of cutting-edge methodologies.

Projects may cover a wide range of topics including omics studies, microbiome interactions, AI applications in bioinformatics, genetic variation studies, translational bioinformatics applicable to personalized medicine, systems biology, and more.

Applications should promote interdisciplinary collaboration and emphasize scalable innovations that yield functional insights into biological phenomena. Key expectations include scientific rigor, feasibility, technological innovation, broad applicability beyond specific diseases, and plans for dissemination of results including software products and datasets.

Eligibility Requirements
Eligible applicants include higher education institutions (public and private), nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), local/state governments, tribal governments, independent school districts, public housing authorities, faith-based organizations, regional organizations, and foreign entities.

Applicants must have the necessary skills and resources to carry out the proposed research.

Period of Performance
The maximum project period is 4 years. The earliest start date for awarded projects is June 5, 2026.

Grant Value
Application budgets are limited to $250,000 per year in direct costs. The total value of the grant awards will depend on NIH appropriations and the number of meritorious applications received.
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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Grant
Grant Program (CFDA)
93.879 - Medical Library Assistance
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 2/11/26 the National Institutes of Health posted grant opportunity PAR-26-040 for Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional) with funding of $2.5 million. The grant will be issued under grant program 93.879 Medical Library Assistance. It is expected that 10 total grants will be made.

Timing

Posted Date
Feb. 11, 2026, 12:00 a.m. EST
Closing Date
March 5, 2029, 12:00 a.m. EST Due in 1001 Days
Last Updated
Feb. 11, 2026, 8:35 a.m. EST
Version
1
Archive Date
May 4, 2029

Eligibility

Eligible Applicants
Public housing authorities/Indian housing authorities
For profit organizations other than small businesses
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
State governments
Native American tribal organizations (other than Federally recognized tribal governments)
Others (see text field entitled "Additional Information on Eligibility" for clarification)
County governments
Private institutions of higher education
Native American tribal governments (Federally recognized)
Special district governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Small businesses
Additional Info
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Award Sizing

Ceiling
$250,000
Floor
Not Listed
Estimated Program Funding
$2,500,000
Estimated Number of Grants
10

Contacts

Contact
National Institutes of Health
Contact Email
nlmprogram@nih.gov
Contact Phone
(301) 402-2541

Documents

Posted documents for PAR-26-040

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