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Zeiss Lattice SIM 5 laser scanning structured illumination super-resolution light microscope and Associated Supplies or Equal

ID: SSN75N98026Q00070 • Type: Sources Sought • Match:  100%
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Description

The U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Cancer Institute (NCI) Center for Cancer Research (CCR), Laboratory of Cancer Biology and Genetics (LCBG), CCR Microscopy Core requires one (1) new, commercially available, Zeiss Lattice SIM5 super-resolution light microscope.

The National Cancer Institute is the principal federal agency for cancer research and training. It leads, conducts, and supports cancer research to advance scientific knowledge and improve cancer prevention, detection, diagnosis, and survivorship. The Center for Cancer Research (CCR) is the largest division of the NCI's intramural research program with both basic and clinical research groups exploring the cutting edge of cancer research involving a wide spectrum of biological and biomedical problems that range from visualizing and understanding the structure of genes and proteins and developing novel assays to detect and potentially treat patients. The CCR Microscopy Core, the main microscopy core in the CCR, serves the imaging needs of a wide range of NCI researchers studying the cell biology of cancer. The core facility has five high-quality research-grade instruments, including confocal, multi-photon and super-resolution microscopes, to apply to the numerous research projects from the over 45 labs/branches within NCI, that use the Core annually. To satisfy the demands for super-resolution fluorescence microscopy, the CCR Microscopy Core requests a new Zeiss Lattice SIM5 structured illumination super-resolution microscope. Structured illumination super-resolution microscopy is an established method for acquiring high resolution images of biological samples and is in high demand from NCI researchers. The demand arises from the need to understand the molecular interactions of cellular proteins and the gene expression profiles of tumor cells. Super-resolution microscopy provides researchers the ability to visualize these molecular interactions within cells, and the newest SIM technology available from the requested Zeiss Latice SIM5 microscope will allow researchers to image these interactions in live cells. Thus, providing this cutting-edge technology to NCI researchers to apply to their cancer research projects and further improve our understanding of the cell biology of cancer.

Background
The U.S. Department of Health and Human Services (HHS), through the National Institutes of Health (NIH) and specifically the National Cancer Institute (NCI), is focused on advancing scientific knowledge and improving cancer prevention, detection, diagnosis, and survivorship.

The NCI's Center for Cancer Research (CCR) is the largest division within NCI's intramural research program, conducting both basic and clinical research on various biological and biomedical problems related to cancer. The CCR Microscopy Core supports imaging needs for over 45 labs/branches within NCI, facilitating cutting-edge cancer research.

To enhance their capabilities in super-resolution fluorescence microscopy, the CCR Microscopy Core requires a new Zeiss Lattice SIM5 structured illumination super-resolution microscope to meet the high demand from researchers aiming to visualize molecular interactions within cells.

Work Details
The contractor is required to provide one (1) new Zeiss Lattice SIM5 laser scanning structured illumination super-resolution light microscope along with associated supplies or equivalent items. Specific project requirements include:
1. Microscope Lattice SIM 3/5 (Part No. 493505-9880-010) - Quantity: 1
2. Axio Observer 7 SR f/Lattice SIM (Part No. 409000-9810-000) - Quantity: 1
3. Autoimmersion module with pipette (Part No. 433801-9040-000) - Quantity: 1
4. Condenser 0.55 mot for SF (Part No. 428400-9000-000) - Quantity: 1
5. Calibration plate for AI Sample Finder for Lattice SIM (Part No. 428400-9210-000) - Quantity: 1
6. Joystick XY; CAN for mechanical stages; CAN, scanning stages; stage controller XY STEP SMC 2009 (Part No. 432903-9012-000) - Quantity: 1
7. Extension cable for stage control (1.6 m) (Part No. 000000-2121-749) - Quantity: 1
8. Stage attachment Z PIEZO WSB 500 (Part No. 432339-9000-000) - Quantity: 1
9. Controller Z PIEZO WSB 500 (Part No. 432339-9010-000) - Quantity: 1
10. Control wheel Z PIEZO WSB 500 (Part No. 432339-9020-000) - Quantity: 1
11. Stage Top incubation heating for Lattice SIM inverted including heating insert, heating cover and controller (Part No. 000000-2519-303) - Quantity: 1
12. Stage top incubator gas system for Lattice SIM inverted (Part No. 000000-2570-331) - Quantity: 1
13. Universal frame insert suitable for cell culture dishes, slides, and chamber slides (Part No. 000000-2623-209) - Quantity: 1
14. Holder frame for slides (Part No. 000000-2519-300) - Quantity: 1
15. Holder frame for chamber slide (Part No. 000000-2519-301) - Quantity: 1
16. Petri dish holding frame D35-40mm (Part No. 000000-2519-299) - Quantity: 1
17. Hold-down for petri dishes in addition to holding frame petri dish D35-40 mm (Part No. 000000-2519-302) - Quantity: 1
18. Halogen lamp (12V,100W GY6.35)(Part No.:3800591660–000)-Quantity :2
19.Additional items include various filters, camera accessories, laser modules, objectives, illuminators and calibration tools as detailed in the solicitation.
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Overview

Agency
HHS Office of the Assistant Secretary for Administration (ASA) [HHS]
Response Deadline
March 13, 2026, 10:00 a.m. EDT Past Due
Posted
Feb. 27, 2026, 1:38 p.m. EST
Set Aside
None
NAICS
None
PSC
None
Place of Performance
Bethesda, MD 20892 United States
Source
Open
Est. Level of Competition
Average
Odds of Award
13%
On 2/27/26 HHS Office of the Assistant Secretary for Administration issued Sources Sought SSN75N98026Q00070 for Zeiss Lattice SIM 5 laser scanning structured illumination super-resolution light microscope and Associated Supplies or Equal due 3/13/26.
Primary Contact
Name
Shayna Simpson   Profile
Email
shayna.simpson@hhs.gov
Phone
None

Secondary Contact

Name
Sanya Jackson   Profile
Email
sanya.jackson@hhs.gov
Phone
None

Documents

Posted documents for Sources Sought SSN75N98026Q00070

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Additional Details

Source Agency Hierarchy
HEALTH AND HUMAN SERVICES, DEPARTMENT OF > OFFICE OF THE ASSISTANT SECRETARY FOR ADMINISTRATION (ASA) > ASA OFFICE OF THE ASSISTANT SECRETARY FOR ADMINISTRATION
FPDS Organization Code
7570-75AJ00
Source Organization Code
500024341
Last Updated
March 28, 2026
Last Updated By
shayna.simpson@hhs.gov
Archive Date
March 28, 2026