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PROactive Solutions for Prolonging Resilience (PROSPR)   2

ID: ARPA-H-SOL-25-125 • Type: Solicitation • Match:  85%
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Description

Posted: May 23, 2025, 9:55 a.m. EDT

23 MAY: The PROSPR Program posting is updated to amend the solicitation. Amendment 2 changes the Solution Summary due date for TA3 submissions and corrects an error in Appedix C. Please reference changes (highlighted in orange) in the solicitation.

22 APR: The PROSPR Program posting is updated to amend the solicitation. Amendment 1 includes two changes to the ISO on pages 28-29 (in orange). No other changes have been made to the solicitation.

4 APR: The PROSPR Program posting is updated to upload the final solicitation. Proposers are invited to visit the PROSPR Program page to view FAQs and a Proposers' Day video.

23 JAN: PROSPR proposers intending to participate in the PROSPR Proposers' Day are encouraged to review ARPA-H Special Notice ARPA-H-SN-25-125. Due to circumstances outside of ARPA-H's control, the PROSPR Proposers' Day event IS CANCELLED. Questions sent to PROSPR@arpa-h.gov ARE UNABLE TO BE ANSWERED AT THIS TIME.

22 JAN: PROSPR proposers intending to participate in the PROSPR Proposers' Day are encouraged to review ARPA-H Special Notice ARPA-H-SN-25-125. Due to circumstances outside of ARPA-H's control, the PROSPR Proposers' Day event will now occur only virtually. Verified/accepted participants are encouraged to verify they have received the Zoom link/invitation. Questions sent to PROSPR@arpa-h.gov will be addressed as quickly as possible.

More information can be found at https://arpa-h.gov/research-and-funding/programs/prospr

Posted: April 22, 2025, 2:14 p.m. EDT
Posted: April 4, 2025, 4:05 p.m. EDT
Posted: April 4, 2025, 2:43 p.m. EDT
Posted: Jan. 23, 2025, 10:32 a.m. EST
Posted: Jan. 23, 2025, 10:32 a.m. EST
Posted: Jan. 22, 2025, 3:49 p.m. EST
Posted: Dec. 23, 2024, 3:17 p.m. EST
Background
The Advanced Research Projects Agency for Health (ARPA-H) is initiating the PROactive Solutions for Prolonging Resilience (PROSPR) program, which aims to enhance the healthspan of Americans by providing an additional 20 years of good health as they age. This program seeks to develop new therapies and create data that enable short-duration clinical trials capable of predicting long-term health outcomes.

The PROSPR program is structured into multiple Technical Areas (TAs), each with specific objectives and deliverables aimed at transforming geriatric medicine into a personalized, comprehensive, preventive care model.

Work Details
The PROSPR program encompasses several Technical Areas (TAs) with detailed tasks:

1. **Technical Area 1 (TA1): PROSPR Intrinsic Capacity Score** - Aimed at developing a composite score that predicts 20-year health outcomes through the following phases:
- Phase I: Develop initial IC score and assessment technology, prepare for clinical observational study.
- Phase II: Refine IC score using observational study data.
- Phase III: Conduct lifestyle intervention study to test IC score's intervenability.
- Phase IV: Further refine IC score and technology based on intervention study data.
- Phase V: Focus on deployment and commercialization of the technology.

2. **Deliverables** include harmonizing existing datasets to identify key physiological and biochemical changes, building in-home assessment technology for continuous monitoring, establishing decentralized lifestyle intervention studies, engaging with the FDA for surrogate endpoint designation, and commercializing the assessment technology at an affordable price.

3. **Collaboration** among performers across TAs is essential for data sharing and integration throughout the program phases.

Place of Performance
The geographic locations for performance are not explicitly stated but may involve various research institutions and clinical settings across the United States.

Overview

Agency
National Institutes of Health (NIH) [HHS]
Response Deadline
June 5, 2025, 2:00 p.m. EDT (original: March 24, 2025, 5:00 p.m. EDT) Past Due
Posted
Dec. 23, 2024, 3:17 p.m. EST (updated: May 23, 2025, 9:55 a.m. EDT)
Set Aside
None
NAICS
541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
PSC
AN13 - Health R&D Services; Health Care Services; Experimental Development
Place of Performance
United States
Source
Open
Links
PROSPR FAQs
PROSPR Program page
Current SBA Size Standard
1000 Employees
Pricing
Likely Fixed Price
Est. Level of Competition
High
On 12/23/24 National Institutes of Health issued Solicitation ARPA-H-SOL-25-125 for PROactive Solutions for Prolonging Resilience (PROSPR) due 6/5/25. The opportunity was issued full & open with NAICS 541715 and PSC AN13.
Primary Contact
Name
The PROSPR Team   Profile
Email
prospr@arpa-h.gov
Phone
None

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Additional Details

Source Agency Hierarchy
HEALTH AND HUMAN SERVICES, DEPARTMENT OF > NATIONAL INSTITUTES OF HEALTH > NIH ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
FPDS Organization Code
7529-75N992
Source Organization Code
500183629
Last Updated
June 20, 2025
Last Updated By
mark.baxter@arpa-h.gov
Archive Date
June 20, 2025