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Organoid Cytomorphic Intelligence Resulting from Convergent Understanding and Information Transfer (O-Circuit)

ID: DARPA-PS-26-28 • Type: Solicitation • Match:  100%
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Description

While semiconductor-based computation is readily deployed in well-resourced environments, it is challenged by sustained applications at the edge' due to inherent power inefficiencies. This is a particular limitation for the Department of War (DoW) when operating in austere environments, especially when using advanced artificial intelligence and machine learning (AI/ML) applications with high energy demands for both training and inference. New unconventional computing concepts, such as synthetic biological intelligence, have the potential to fundamentally address these limitations but do not yet possess the necessary training and inference capabilities for practical applications. To meet these needs, the O-Circuit program will explore methods for improving the learning, inference, and computational memory of neural tissue systems to develop an integrated biological processing unit (BPU) that establishes a new paradigm for sense-compute-act for edge applications.
Background
The O-Circuit program, initiated by the Department of War (DoW), aims to address the challenges of deploying semiconductor-based computation in austere environments, particularly for advanced artificial intelligence and machine learning applications that require high energy.

The program seeks to explore unconventional computing concepts, such as synthetic biological intelligence, to enhance the learning, inference, and computational memory of neural tissue systems. The goal is to develop an integrated biological processing unit (BPU) that can facilitate a new paradigm for sense-compute-act operations in edge applications.

Work Details
The contract involves several key tasks and services:
- Development of BPU architectures that provide significant computational learning and memory capabilities (TA1).
- Integration of BPUs with odorant sensory arrays and drone navigation systems to enhance multiplexed odorant detection capabilities and chemotaxis (TA2).
- Exploration of new BPU architectures during Phase 1, focusing on quantifying their capacity for computational learning and memory.
- Refinement of BPU systems in Phase 2 to improve performance metrics such as learning efficiency and memory duration for TA1, and detection accuracy for TA2.
- Collaboration between TA1 and TA2 performers to identify teaming strategies for a comprehensive Phase 3 effort that integrates both components into a cohesive Sense-Compute-Action system.
- Ethical considerations must be included in proposals, addressing potential bioethics concerns related to biological computation advancements.

Period of Performance
The contract will be executed over a total period of 32 months, divided into Phase 1 lasting 18 months and Phase 2 lasting 14 months.

Place of Performance
The geographic locations for the performance of this contract are not explicitly provided in the solicitation.

Overview

Response Deadline
May 20, 2026, 1:00 p.m. EDT Due in 14 Days
Posted
May 1, 2026, 4:17 p.m. EDT
Set Aside
None
Place of Performance
Not Provided
Source

Current SBA Size Standard
1000 Employees
Pricing
Multiple Types Common
Est. Level of Competition
High
On 5/1/26 Defense Advanced Research Projects Agency issued Solicitation DARPA-PS-26-28 for Organoid Cytomorphic Intelligence Resulting from Convergent Understanding and Information Transfer (O-Circuit) due 5/20/26. The opportunity was issued full & open with NAICS 541714 and PSC AC12.
Primary Contact
Name
Dr. Jeffrey Zaleski, Program Manager, DARPA/BTO   Profile
Phone
None

Documents

Posted documents for Solicitation DARPA-PS-26-28

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Additional Details

Source Agency Hierarchy
DEPT OF DEFENSE > DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) > DEF ADVANCED RESEARCH PROJECTS AGCY
FPDS Organization Code
97AE-HR0011
Source Organization Code
500035490
Last Updated
May 1, 2026
Last Updated By
darpa.fbo.gov@darpa.mil
Archive Date
June 19, 2026