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NOI - Dynamic Genome: CHIP

ID: 75N98026Q00362 • Type: Synopsis Solicitation • Match:  90%
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Description

This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.
(ii) The solicitation number is 75N98026Q00362 and the solicitation is issued as a Notice of Intent (NOI) of a non-competitive (notice of intent) combined synopsis solicitation to award a contract or purchase order without providing for full or open competition (including brand-name).
This acquisition is conducted under the authority of the FAR Part 12.603 Streamlined solicitation for commercial products or commercial services, and is not expected to exceed the simplified acquisition threshold, and the authority of 41 U.S.C. 1901 and the statutory authority of FAR 6.302-3(a)(2)(ii).
The National Institutes of Health, Office of the Director, Office of Acquisitions, intends to negotiate and award a firm-fixed-price purchase order without providing for full and open competition (Including brand-name) to Vanderbilt University Medical Center
1161 21st Ave S, Suite D3300 MCN Nashville, TN 37232-0001 for specialized computational analysis services to identify clonal hematopoiesis of indeterminate potential (CHIP) in longitudinal whole genome sequencing datasets.
This requirement is a follow-on effort to previously completed work performed by the same vendor. Continuation with the same source is necessary to maintain methodological consistency across longitudinal datasets, ensure reproducibility of prior analyses, and avoid duplication of cost and schedule delays associated with revalidation of analytical pipelines.
Background
The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, is issuing this combined synopsis/solicitation to award a firm-fixed-price purchase order to Vanderbilt University Medical Center for specialized computational analysis services. This acquisition is a follow-on effort to previously completed work by the same vendor, necessary for maintaining methodological consistency across longitudinal datasets and ensuring reproducibility of prior analyses related to clonal hematopoiesis of indeterminate potential (CHIP).

The goal is to support ongoing research into cardiovascular disease and related conditions using whole genome sequencing datasets.

Work Details
The contractor will perform specialized bioinformatics and computational analysis services to identify CHIP using whole genome sequencing (WGS) data from the Framingham Heart Study. Tasks include:
1) Performing longitudinal analysis of WGS data from two timepoints (greater than 10 years apart), including recalibration of prior datasets;
2) Detecting somatic mutations;
3) Identifying CHIP using validated analytical pipelines;
4) Collaborating with the NHLBI intramural team led by Dr. Dan Levy on subsequent analyses and publications.

The work requires consistency with prior analyses to support accurate longitudinal comparison.

Period of Performance
The contract will be performed from June 1, 2026, to September 30, 2026.

Place of Performance
Services shall be performed at the contractor's facility, with data accessed remotely via dbGaP and the TOPMed Data Exchange.

Overview

Response Deadline
May 29, 2026, 9:00 a.m. EDT Due in 11 Days
Posted
May 15, 2026, 8:12 a.m. EDT
Set Aside
None
Place of Performance
1161 21st Ave S, Suite D3300 MCN Nashville, TN 37232-0001 USA
Source

Current SBA Size Standard
$19.5 Million
Pricing
Fixed Price
Est. Level of Competition
Sole Source
Est. Value Range
Experimental
$50,000 - $250,000 (AI estimate)
On 5/15/26 NIH Office of Logistics and Acquisition Operations issued Synopsis Solicitation 75N98026Q00362 for NOI - Dynamic Genome: CHIP due 5/29/26. The opportunity was issued full & open with NAICS 541990 and PSC B529.
Primary Contact
Name
CAPOBIANCO, NICHOLAS S   Profile
Phone
+1 000 000 0000

Documents

Posted documents for Synopsis Solicitation 75N98026Q00362

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Additional Details

Source Agency Hierarchy
HEALTH AND HUMAN SERVICES, DEPARTMENT OF > NATIONAL INSTITUTES OF HEALTH > NATIONAL INSTITUTES OF HEALTH OLAO
FPDS Organization Code
7529-75N980
Source Organization Code
100189057
Last Updated
May 15, 2026
Last Updated By
nicholas.capobianco@nih.gov
Archive Date
June 13, 2026