Development of a versatile small footprint benchtop device to perform batch evaporation

(Fast-Track proposals will not be accepted. Phase II information is provided only for informational purposes to assist Phase I offerors with their long-term strategic planning.) Number of anticipated awards: 1 to 3 Budget (total costs, per award): Phase I: $325,000 for 9-12 months; Phase II: $2,000,000 for 2 years It is strongly suggested that proposals adhere to the above budget amounts and project periods. Proposals with budgets exceeding the above amounts and project periods may not be funded. Summary: The objective of this contract is to develop a versatile, small footprint benchtop device capable of performing efficient batch evaporation for integration into automated chemical synthesis (ACS) workflows. The proposed device will address the significant bottlenecks in the current evaporation processes by enabling simultaneous evaporation of multiple high recovery vials, achieving 90% evaporation in under 10 minutes for common solvents, and being fully automation friendly. This innovation will enhance the throughput, efficiency, and integration capabilities of ACS workflows, ultimately supporting the broader research community's efforts in organic chemical synthesis. The National Center for Advancing Translational Sciences (NCATS) has developed a prototype batch evaporation device using intramural resources as part of the ASPIRE (A Specialized Platform for Innovative Research Exploration) program. This innovative benchtop device is designed to overcome the key bottlenecks in automated chemical synthesis (ACS) workflows by enabling efficient, simultaneous evaporation of multiple high recovery vials. The prototype had the following key features: Design: Compact, user-friendly benchtop device capable of fitting within a standard chemical fume hood. Capacity: Capable of evaporating up to 4 high recovery vials simultaneously. Efficiency: Achieves 90% total evaporation of common solvents in under 10 minutes. Page 79 Automation: Equipped with an application programming interface (API) for seamless integration into ACS workflows.