Search Contract Opportunities

Developing selective small-molecule inhibitors of

ID: 75N98026Q00986 • Type: Solicitation • Match:  95%
Opportunity Assistant

Hello! Please let me know your questions about this opportunity. I will answer based on the available opportunity documents.

Please sign-in to link federal registration and award history to assistant. Sign in to upload a capability statement or catalogue for your company

Popular Questions:
Generate a draft:

Description

Background
The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, is seeking to award a Firm-Fixed-Price contract for developing selective small-molecule inhibitors of NNMT for chronic kidney disease. NIH is the leading medical research agency in the U.S., aiming to enhance health and reduce illness through medical discoveries.

The National Center for Advancing Translational Sciences (NCATS) is involved in this project, focusing on innovative methods for diagnostics and therapeutics across various diseases.

Work Details
The contractor will conduct pharmacokinetic (PK/PD) studies on three NNMT inhibitors in mice following both intravenous (IV) and oral (PO) administration at predetermined single doses. The study will involve monitoring plasma concentrations of the parent compound and 1-MNA at specified time points: 0, 5, 15, 30 minutes, 1, 2, 4, 8, 12, and 24 hours post-dose.

Deliverables include blood work results and PK results presented in an Excel report. Results must be sent to designated NCATS personnel via email within three weeks after completion of each study.

Period of Performance
09/04/2026 to 03/03/2027

Place of Performance
NIH/NCATS- 9808 Medical Center Drive, Rockville, MD 20850

Bidder Requirements
The contractor must provide qualified personnel including at least one PhD-level manager and one PhD-level scientist for the estimated level of effort over three months. There are no specific security clearances or licenses mentioned; however, bidders should have relevant experience in conducting pharmacokinetic studies.
(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes only solicitation; proposals are being requested, and a separate written solicitation will not be issued.
(ii) The solicitation number is 75N98026Q00986. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.
This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold (if applicable).
The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a (Firm-Fixed-Price) to the offeror responsible whose proposal represents the best value to the Government.
(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular effective August 7, 2026
(iv) The associated NAICS code is 325414 Biological Product (except Diagnostic) Manufacturing and the small business size standard is 1250 Employees.
This requirement is unrestricted.

Overview

Agency
NIH Office of Logistics and Acquisition Operations (OLAO) [HHS - NIH]
Response Deadline
Due in 16 Days
Posted
Set Aside
None
NAICS
541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
PSC
Q301 - Reference Laboratory Testing
Place of Performance
Not Provided
Source
Open
Current SBA Size Standard
1000 Employees
Pricing
Fixed Price
Evaluation Criteria
Best Value
Est. Level of Competition
High
Est. Value Range
Experimental
$50,000 - $250,000 (AI estimate)
On 8/7/26 NIH Office of Logistics and Acquisition Operations issued Solicitation 75N98026Q00986 for Developing selective small-molecule inhibitors of due 8/24/26. The opportunity was issued full & open with NAICS 541715 and PSC Q301.
Primary Contact
Name
JOHNSTON, JADDUA C   Profile
Email
jaddua.johnston@nih.gov
Phone
+1 000 000 0000

Documents

Posted documents for Solicitation 75N98026Q00986

Opportunity Assistant

AI Analysis
AI Generate

Incumbent or Similar Awards

Potential Bidders and Partners

Awardees that have won contracts similar to Solicitation 75N98026Q00986

Similar Active Opportunities

Open contract opportunities similar to Solicitation 75N98026Q00986

Experts for Developing selective small-molecule inhibitors of

Recommended subject matter experts available for hire

Additional Details

Source Agency Hierarchy
HEALTH AND HUMAN SERVICES, DEPARTMENT OF > NATIONAL INSTITUTES OF HEALTH > NATIONAL INSTITUTES OF HEALTH OLAO
FPDS Organization Code
7529-75N980
Source Organization Code
100189057
Last Updated
Last Updated By
jaddua.johnston@nih.gov
Archive Date