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Auto Droplet Generator

ID: NIDDK07396 • Type: Special Notice • Match:  100%
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Description

Background
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is part of the National Institutes of Health and focuses on studying pancreatic islet organoids derived from induced pluripotent stem cells to investigate molecular pathways associated with type 2 diabetes.

The laboratory has recently acquired a QX600 Droplet Digital Polymerase Chain Reaction system to enhance their research capabilities. Bio-Rad Laboratories, Inc. is the sole source identified for the Auto Droplet Generator, which is essential for automating droplet generation in their workflows.

Work Details
The contract involves the procurement of an Auto Droplet Generator that will automate droplet generation for droplet digital polymerase chain reaction workflows.

This system aims to reduce hands-on processing time and improve throughput and consistency across experiments involving pancreatic islets and islet organoids. The Auto Droplet Generator will replace the current Manual Droplet Generator, which can only process up to eight samples at a time, making it inefficient for preparing a full 96-well plate.

Period of Performance
The anticipated award will be issued approximately five days after the notice date.

Place of Performance
Bethesda MD 20892 UNITED STATES

Bidder Requirements
Bio-Rad Laboratories, Inc. is identified as the only known responsible source capable of providing the Auto Droplet Generator that meets NIDDK's standards. Other small businesses may submit a written capability statement demonstrating their ability to meet the requirements.

The Diabetes Molecular Genetics Section of the Phoenix Epidemiology and Clinical Research Branch at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) studies pancreatic islet organoids derived from induced pluripotent stem cells to investigate molecular pathways associated with type 2 diabetes. The laboratory recently acquired a QX600 Droplet Digital Polymerase Chain Reaction system to generate cell type-specific gene expression data, perform methylation analysis for epigenomic studies, and estimate pancreatic islet composition using cell type-specific marker genes.

Currently, the laboratory uses a Manual Droplet Generator to prepare samples for droplet digital polymerase chain reaction analysis. Although the system can process up to eight samples at a time, preparation of a full 96-well plate is time-consuming and relies heavily on manual pipetting.

The Auto Droplet Generator shall automate droplet generation for droplet digital polymerase chain reaction workflows, reduce hands-on processing time, and improve throughput and consistency across experiments involving pancreatic islets and islet organoids.

Overview

Response Deadline
Due in 5 Days
Posted
Set Aside
None
Place of Performance
Bethesda, MD 20892 United States
Source

Current SBA Size Standard
1000 Employees
Pricing
Fixed Price
Est. Level of Competition
Sole Source
Est. Value Range
Experimental
$60,000 - $120,000 (AI estimate)
On 9/17/26 Department of Health and Human Services issued Special Notice NIDDK07396 for Auto Droplet Generator due 9/23/26.
Primary Contact
Name
Darin Mahkee
Phone
None

Documents

Posted documents for Special Notice NIDDK07396

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Additional Details

Source Agency Hierarchy
HEALTH AND HUMAN SERVICES, DEPARTMENT OF
FPDS Organization Code
7500-7500
Source Organization Code
100004222
Last Updated
Last Updated By
hairstonr@od.nih.gov
Archive Date