0000001183

THE JACKSON LABORATORY SITE (SITE #3): LEONARD (LENNY) SHULTZ, PHD (PROFESSOR) OF THE JACKSON LABORATORY (JAX) WILL SERVE AS CO-I AND SUBAWARD CONTRACTOR FOR THE JAX SITE (SITE #3). DR.SHULTZ WILL DEVELOP, VALIDATE, AND PROVIDE GENETIC STOCKS OF NSG MICE (AND VARIANTS) NEEDED FOR HUMANIZATION STUDIES. HIS LABORATORY WILL MAINTAIN AND PROVIDE NSG AND NSG- FLT3L MICE TOSITE #1 AND SITE #2 TEAM MEMBERS, AND DEVELOP/OPTIMIZE THE NSG-FLT3L MOUSE 1)INCORPORATING HUMAN CLASS I AND II HLA TRANSGENES FOR THE PURPOSE OF HUMANIZING WITHOUT THENEED FOR HUMAN THYMUS TISSUE I.E. CORD BLOOD CD34+ CELLS ONLY, AND 2) INCORPORATING THE KITW41 ALLELE TO ELIMINATE THE REQUIREMENT OF IRRADIATION/ABLATION FOR HEMATOPOIETIC ENGRAFTMENT AND ROBUST HUMAN CHIMERISM. DR. SHULTZ WILL COORDINATE ACTIVITIES WITH THE PI AND OTHER CO-I TO ENSURE THAT MILESTONES ARE MET, AND WILL ALSO WORK WITH JAX TRAINING COORDINATORS AND THE UW SITE TO FACILITATE TRAINING SESSIONS APPLICABLE TO THE HUMANIZED MICE DEVELOPED AND OPTIMIZED UNDER THE CONTRACT. KEY PERSONNEL LISA CARNEY (LABORATORY MANAGER) IN THE SHULTZ LABORATORY WILL OVERSEE PRODUCTION OF MOUSE STOCKS AND VALIDATE THEIR PHENOTYPES WITH AN ARRAY OF ASSAYS, INCLUDING FLOW CYTOMETRY, HISTOLOGY, AND ELISAS. THE SHULTZ LAB HAS FIVE TOTAL STAFF, TWO OF WHOM ARE AVAILABLE TO BE ASSIGNED TO THE CONTRACT. NO ADDITIONAL STAFF WILL BE HIRED UPON AWARD OF THE CONTRACT.

Jackson Laboratory

$653,172.00

Feb. 28, 2023

Bar Harbor, Maine 04609-1523 United States

University Of Wisconsin System

None

75N93021C00004

CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)

National Institute of Allergy and Infectious Diseases (NIAID) [HHS - NIH]

Not Reported

AN12 - Health R&D Services; Health Care Services; Applied Research

Cost No Fee

Madison, WI 53715 United States

None

Full And Open Competition