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Specialized Center Cooperative Agreements in Aging and/or Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) Research

ID: PAR-25-461 • Type: Forecasted
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Description

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit new, renewal, and competing revision applications, and their resubmissions, for U54 Specialized Center cooperative agreements that support large-scale, complex research projects with multiple highly integrated components focused on a common research question relevant to aging and/or Alzheimer's Disease (AD) and AD-related dementias (ADRD) research. It is anticipated that such projects will likely involve an integrated multidisciplinary team of investigators within a single institution or a consortium of institutions. If submitting renewal or revision applications the research objectives and scope of applications submitted through this NOFO must adhere to the requirements outlined in the parent NOFO under which the original application was funded.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Prospective applicants are strongly encouraged to contact NIA program staff prior to applying to discuss the responsiveness of their proposed research to this NOFO and its relevance to NIA's programmatic priorities. Applicants should be aware that NIA anticipates funding only a limited number of meritorious applications under this announcement. Given this high level of competition, consultation with program staff will help applicants determine whether their proposed project is a good fit for the goals and priorities of this NOFO.

Background
The National Institute on Aging (NIA) is issuing a Notice of Funding Opportunity (NOFO) to solicit applications for U54 Specialized Center cooperative agreements. These agreements aim to support large-scale, complex research projects focused on aging, Alzheimer's Disease (AD), and AD-related dementias (ADRD). The goal is to foster multidisciplinary collaborations among investigators within single institutions or consortia.

Grant Details
The grant will support large-scale research projects that have multiple highly integrated components centered around a common research question relevant to aging and/or Alzheimer's Disease and AD-related dementias. Projects must involve an integrated multidisciplinary team of investigators. Renewal or revision applications must adhere to the requirements outlined in the parent NOFO under which the original application was funded. While applications are not currently being solicited, potential applicants are encouraged to develop collaborations and discuss their proposed research with NIA program staff to ensure alignment with NIA’s priorities.

Eligibility Requirements
Eligibility is open to institutions capable of forming multidisciplinary teams for large-scale research projects. Applicants are encouraged to consult with NIA program staff prior to submission.

Period of Performance
The period of performance will be determined upon the awarding of grants. It is expected that projects will span multiple years as they involve complex research initiatives.

Grant Value
The total value of the grant and potential individual awards has not been specified in the document.

Place of Performance
The specific geographic locations for performing the grant activities have not been detailed in the document.
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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Program (CFDA)
93.866 - Aging Research
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 1/20/26 the National Institutes of Health forecasted grant opportunity PAR-25-461 for Specialized Center Cooperative Agreements in Aging and/or Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) Research. The grant will be issued under grant program 93.866 Aging Research.

Timing

Forecast Posted Date
Jan. 20, 2026, 12:00 a.m. EST
Est. Application Posting Date
April 25, 2026, 12:00 a.m. EDT
Est. Synopsis Response Date
June 26, 2026, 12:00 a.m. EDT Forecasted
Last Updated
Jan. 20, 2026, 1:56 p.m. EST
Version
1

Eligibility

Eligible Applicants
Special district governments
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
Private institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
State governments
Native American tribal governments (Federally recognized)
City or township governments
For profit organizations other than small businesses
Additional Info
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations.

Contacts

Contact
NIA Scientific Contact
Contact Email
nia-nofo-scientific@nih.gov
Email Description
NIA-NOFO-Grants@nih.gov

Documents

Posted documents for PAR-25-461

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