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Novel Approaches to Advance Precision Aging and Cognitive Health

ID: RFA-AG-26-022 • Type: Forecasted
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Description

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that develop or incorporate novel, cutting-edge study designs/methods/analytic approaches through the use of machine learning, artificial intelligence, and adaptive designs to allow the discovery of health/function profiles at the level of the individual and that could lead to the implementation of personalized prevention plans/interventions for cognitive/brain health in older adults. The initiative would allow for both basic research in animal models, as well as the development of profiles for humans, which would span levels of analysis from cellular to societal.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.

Background
The National Institute on Aging (NIA) is planning to publish a Notice of Funding Opportunity (NOFO) aimed at soliciting applications that focus on developing or incorporating innovative study designs, methods, and analytic approaches utilizing machine learning, artificial intelligence, and adaptive designs.

The goal is to discover health and function profiles at the individual level that could lead to personalized prevention plans and interventions for cognitive and brain health in older adults. This initiative encompasses both basic research in animal models and the development of human profiles across various levels of analysis from cellular to societal.

Grant Details
The NOFO will utilize the R01 activity code. It encourages investigators with expertise in aging research to consider applying once the application process opens. The focus is on novel approaches that advance precision aging and cognitive health through cutting-edge methodologies.

Eligibility Requirements
Investigators with expertise in aging research are encouraged to apply. Specific eligibility criteria will be detailed when the application process opens.

Period of Performance
The specific period of performance has not been defined yet, as applications are not currently being solicited.

Grant Value
The total value of the grant and potential value of individual grant awards have not been specified in the current notice.

Place of Performance
The geographic location(s) for performing the grant activities have not been provided.
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Overview

Agency
National Institutes of Health (NIH) [HHS]
Category of Funding
Health
Funding Instruments
Grant
Grant Program (CFDA)
93.866 - Aging Research
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
Grants.gov
On 11/24/25 the National Institutes of Health forecasted grant opportunity RFA-AG-26-022 for Novel Approaches to Advance Precision Aging and Cognitive Health. The grant will be issued under grant program 93.866 Aging Research.

Timing

Forecast Posted Date
Nov. 24, 2025, 12:00 a.m. EST
Est. Application Posting Date
Aug. 6, 2026, 12:00 a.m. EDT
Est. Synopsis Response Date
Oct. 6, 2026, 12:00 a.m. EDT Forecasted
Last Updated
Nov. 24, 2025, 7:02 a.m. EST
Version
1

Eligibility

Eligible Applicants
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Small businesses
Special district governments
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Private institutions of higher education
Public housing authorities/Indian housing authorities
State governments
County governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
Native American tribal organizations (other than Federally recognized tribal governments)
City or township governments
Additional Info
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Contacts

Contact
Molly Wagster, Ph.D.
Contact Email
wagsterm@nia.nih.gov

Documents

Posted documents for RFA-AG-26-022

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