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Infectious Diseases Clinical Trials Network (IDCTN)

ID: RFA-AI-27-002 • Type: Forecasted
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Description

The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by supporting a cooperative network to rapidly implement clinical trials that meet NIH and NIAID priorities. The network, comprised of the Clinical Trial Evaluation Units (CTEUs) and a Network Coordination Center (NCC), supports the evaluation of therapeutics, vaccines, biologics, diagnostics, and devices targeting infectious diseases, including emerging and chronic infections. The initiative gives the NIH the capabilities to conduct clinical trials and studies for public health priorities, where the timelines of a standard, unsolicited grant would not adequately address the needs of the United States population. The CTEUs provide the clinical infrastructure for implementing the clinical trials and studies. The NCC, comprised of leaders from the CTEUs in collaboration with NIAID, provides the administrative and organizational framework of the network, engages with experts in the field to solicit and generate innovative concepts for advancing public health while mentoring the next generation of clinical trialists. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

Background
The National Institute of Allergy and Infectious Diseases (NIAID) aims to advance its mission by supporting a cooperative network for the rapid implementation of clinical trials that align with NIH and NIAID priorities. This initiative is designed to address public health needs through the evaluation of therapeutics, vaccines, biologics, diagnostics, and devices targeting infectious diseases, including emerging and chronic infections.

The network consists of Clinical Trial Evaluation Units (CTEUs) and a Network Coordination Center (NCC), which together provide the necessary infrastructure and administrative framework for conducting clinical trials efficiently.

Grant Details
The grant supports the establishment of a cooperative network that includes Clinical Trial Evaluation Units (CTEUs) and a Network Coordination Center (NCC). The CTEUs are responsible for implementing clinical trials and studies, while the NCC collaborates with CTEU leaders to provide organizational support, engage experts in generating innovative concepts for public health advancements, and mentor future clinical trialists.

The grant will facilitate the evaluation of various medical interventions targeting infectious diseases.

Eligibility Requirements
Eligible applicants include institutions or organizations capable of conducting clinical trials in alignment with NIAID's mission. There may be preferences for those with prior experience in infectious disease research or clinical trial management.

Period of Performance
The period of performance for this grant opportunity is expected to align with the timelines necessary to address urgent public health needs.

Grant Value
The total value of the grant opportunity has not been specified in the provided text. However, it is implied that funding will be allocated based on the scope and requirements of the proposed clinical trials.

Overview

Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
On 11/18/25 the National Institutes of Health forecasted grant opportunity RFA-AI-27-002 for Infectious Diseases Clinical Trials Network (IDCTN) with funding of $29.0 million. The grant will be issued under grant program 93.855 Allergy and Infectious Diseases Research.

Timing

Forecast Posted Date
Nov. 18, 2025, 12:00 a.m. EST
Est. Application Posting Date
March 13, 2026, 12:00 a.m. EDT
Est. Synopsis Response Date
June 11, 2026, 12:00 a.m. EDT Forecasted
Last Updated
Nov. 18, 2025, 10:36 a.m. EST
Version
1

Eligibility

Eligible Applicants
Special district governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Private institutions of higher education
State governments
Small businesses
Public and State controlled institutions of higher education
City or township governments
County governments
Additional Info
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations.

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
$29,000,000
Estimated Number of Grants
Not Listed

Contacts

Contact
Marina S. Lee, Ph.D.

Documents

Posted documents for RFA-AI-27-002

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