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Global Brain and Nervous System Disorders Research Across the Lifespan - Exploratory Grants

ID: PAR-25-456 • Type: Forecasted
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Description

The Fogarty International Center, with NINDS, NIMH, NIA, NIEHS, NICHD, NEI, NIDCD, and NCCIH, intends to continue support of neuro-health research through the Global Brain and Nervous System Disorders Research Across the Lifespan program. Awards will catalyze and strengthen collaborative research on the brain and nervous system that leverages the unique scientific contexts of low- and middle-income countries (LMICs) not readily present in the United States and, subsequently, optimizes our potential to address health needs in the U.S. and globally. Research on the full spectrum of neuro-health across the lifespan is encouraged - including neurological, neuromuscular, sensory, neuropsychiatric, neuroinfectious, cognitive, behavioral, and neurodevelopmental disease - and encompassing basic, clinical, translational, and implementation research approaches. Projects will foster collaborations between scientists in the U.S. and LMICs to drive scientific advancement and the development of innovative, cost-effective interventions spanning the care continuum from diagnosis through treatment and implementation.

Background
The Fogarty International Center, in collaboration with NINDS, NIMH, NIA, NIEHS, NICHD, NEI, NIDCD, and NCCIH, aims to support neuro-health research through the Global Brain and Nervous System Disorders Research Across the Lifespan program. This initiative seeks to catalyze and strengthen collaborative research on brain and nervous system disorders in low- and middle-income countries (LMICs), addressing health needs both domestically and globally.

The program encourages research across a full spectrum of neuro-health issues throughout the lifespan, including various neurological and neurodevelopmental diseases.

Grant Details
The grant will support projects that foster collaborations between scientists in the U.S. and LMICs. Research is encouraged across basic, clinical, translational, and implementation approaches to drive scientific advancement and develop innovative interventions that span the care continuum from diagnosis through treatment. The focus includes neurological, neuromuscular, sensory, neuropsychiatric, neuroinfectious, cognitive, behavioral, and neurodevelopmental diseases.

Eligibility Requirements
Eligibility is open to U.S. institutions collaborating with researchers in low- and middle-income countries. Preference may be given to applications that demonstrate strong partnerships between U.S. researchers and LMIC institutions.

Period of Performance
The period of performance for this grant will be determined based on project proposals but is expected to encompass multiple years to allow for comprehensive research development.

Grant Value
The total value of the grant opportunity is not explicitly stated; however, individual grant awards will vary based on project scope and funding availability.

Place of Performance
Research activities are expected to take place in both the United States and low- and middle-income countries involved in the collaborative projects.

Overview

Category of Funding
Health
Funding Instruments
Grant
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
On 9/26/25 the National Institutes of Health forecasted grant opportunity PAR-25-456 for Global Brain and Nervous System Disorders Research Across the Lifespan - Exploratory Grants. The grant will be issued under grant program 93.989 International Research and Research Training.

Timing

Forecast Posted Date
Sept. 26, 2025, 12:00 a.m. EDT
Est. Application Posting Date
Dec. 23, 2025, 12:00 a.m. EST
Est. Synopsis Response Date
Feb. 24, 2026, 12:00 a.m. EST Forecasted
Last Updated
Sept. 26, 2025, 7:56 a.m. EDT
Version
1

Eligibility

Eligible Applicants
Independent school districts
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
State governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
City or township governments
For profit organizations other than small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
Native American tribal governments (Federally recognized)
Private institutions of higher education
County governments
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Info
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions)Non-domestic applicant organizations are restricted to organizations in low- and middle-income countries (LMICs), which are defined by the World Bank as low-, lower-middle-, or upper-middle-income economies. At least one organization in the U.S. and at least one organization in a LMIC must be involved as partners in each application.

Contacts

Contact
UnJa Hayes
Contact Email

Documents

Posted documents for PAR-25-456

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