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BRAIN Initiative: Brain-Behavior Quantification and Synchronization – Transformative Research on Behavior at the Organismal Level

ID: RFA-DA-27-011 • Type: Forecasted
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Description

The Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a collaboration of Federal and non-Federal partners led by NIH, seeks to accelerate development and dissemination of new neurotechnologies, transdisciplinary approaches, and scientific databases to study brain function with unprecedented resolution and scope. The BRAIN Initiative's Brain Behavior Quantification and Synchronization (BBQS) Program furthers this mission by supporting the development of tools for high-resolution, multimodal tracking of complex behaviors synchronously with neural activity and advancement of theoretical frameworks and computational models for understanding neurobehavioral function in real-world settings. This BRAIN Initiative-funded BBQS opportunity will support transdisciplinary research involving human subjects and/or other species aiming to advance methods to capture and model complex behavior at the organismal level in dynamic environments. Required objectives include advancing sensing technologies and approaches for minimally intrusive, high-resolution, synchronous measurement of multiple biobehavioral functions (e.g. movements, peripheral physiology and neural activity) with simultaneous, multi-level tracking of environmental variables; and developing analytic and computational approaches that will lead to new, testable models of neurobehavioral function as a complex dynamic system shaped by the organism's environment. Participation in consortium activities will be required. This forecast is authorized under 42 U.S.C. 241&284 and 114 U.S.C. 255.

Background
The Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative, led by NIH, aims to accelerate the development and dissemination of new neurotechnologies and scientific databases to study brain function.

The BRAIN Initiative’s Brain Behavior Quantification and Synchronization (BBQS) Program supports transdisciplinary research that advances methods for capturing and modeling complex behavior at the organismal level in dynamic environments.

Grant Details
The BBQS opportunity will support the development of tools for high-resolution, multimodal tracking of complex behaviors alongside neural activity.

Required objectives include:
- Advancing sensing technologies for minimally intrusive, high-resolution measurement of multiple biobehavioral functions (e.g., movements, peripheral physiology, and neural activity) with simultaneous tracking of environmental variables.
- Developing analytic and computational approaches that lead to new models of neurobehavioral function as a complex dynamic system influenced by the environment.

Participation in consortium activities is mandatory.

Eligibility Requirements
Eligible applicants include researchers conducting transdisciplinary research involving human subjects and/or other species. There are no specific preferences mentioned for eligibility.

Period of Performance
The period of performance is expected to be from January 21, 2022, to February 14, 2030.

Grant Value
The total value of the grant has not been specified in the provided text.

Place of Performance
The specific geographic locations for the performance of this grant have not been detailed.

Overview

Category of Funding
Health
Funding Instruments
Cooperative Agreement
Grant Category
Discretionary
Cost Sharing / Matching Requirement
False
Source
On 1/26/26 the National Institutes of Health forecasted grant opportunity RFA-DA-27-011 for BRAIN Initiative: Brain-Behavior Quantification and Synchronization – Transformative Research on Behavior at the Organismal Level with funding of $8.0 million. The grant will be issued under grant program 93.372 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies. It is expected that 10 total grants will be made.

Timing

Forecast Posted Date
Jan. 26, 2026, 12:00 a.m. EST
Est. Application Posting Date
June 25, 2026, 12:00 a.m. EDT
Est. Synopsis Response Date
Oct. 13, 2026, 12:00 a.m. EDT Forecasted
Last Updated
Jan. 26, 2026, 9:31 a.m. EST
Version
1

Eligibility

Eligible Applicants
County governments
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
Special district governments
Native American tribal governments (Federally recognized)
Independent school districts
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
For profit organizations other than small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
State governments
Private institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Info
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Award Sizing

Ceiling
Not Listed
Floor
Not Listed
Estimated Program Funding
$8,000,000
Estimated Number of Grants
10

Contacts

Contact
The Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative
Contact Email
Email Description
Scientific Contact, BBQS Organismal Behavior

Documents

Posted documents for RFA-DA-27-011

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