FA865022C6454

Small Technology Transfer Research Program (STTR) Phase II

Bioprinted Organoids for Physiological Monitoring

3D-Bioprinted Living System for Sensor Development

Airmen face exposure to a variety of potentially hazardous environments including exposure to hazardous chemicals such as jet fuel, energetic materials, paints, and other toxicants. Further, the conditions that will be experienced by members of the U.S. Space Force such as radiation, microgravity, etc. can have significant physiological impact on warfighter performance. Of the many dangers Airmen face, the hypoxia-like unexplained physiological events (UPEs) are some of the most dangerous and elusive. Current wearable sensors cannot decouple complex, interdependent in vivo response. The goal of this project is to develop (design, fabricate, test, and demonstrate) a portable platform containing bioprinted organoids that recapitulates human-level architectures, with integrated sensors that can monitor both environmental conditions and physiological markers to provide real time feedback to pilots during flight, as well as data logging for further analysis on the ground. In Phase I, proof of concept of key technology elements including bioprinted organoids and sensors was demonstrated. The proposed Phase II research builds on the successful Phase I accomplishments and will further optimize the components of the platform and will focus on the development and characterization of a stand-alone portable platform.

The goal of phase II is to continue the R&D efforts initiated in Phase I. Funding is based on the results achieved in Phase I and the scientific and technical merit and commercial potential of the project proposed in Phase II. STTRs are completed in conjunction with a research institution.

Baylor University

AF19A-T002

F19A-002-0136

19.A

Tanu Singhal